None listed
Conditions
Brief summary
This research study aims to explore intra-individual variability in symptoms over time and intra-individual predictors of symptom severity. A series of n-of-1 observational studies with individuals with ME/CFS will be conducted. The study also aims to assess the acceptability and feasibility of participating in n-of-1 observational studies from the perspective of individuals with ME/CFS. This will be achieved by conducting semi-structured interviews with participants at the end of the study and by examining participant adherence to study procedures (e.g. questionnaire completion rates).
Interventions
ME/CFS is a complex, multi-system, neuroimmune condition with a multitude of symptoms. Some symptoms include post-exertional fatigue/malaise, sleep problems/disturbances, joint and muscle pain, headaches, short-term memory loss, impaired concentration, hypersensitivity to light and sound, emotional overload, problems with dizziness and balance, recurrent flu-like symptoms, gastrointestinal problems and sensitivities to food, medications, odours or certain chemicals. It is common for patients to
ME/CFS is a complex, multi-system, neuroimmune condition with a multitude of symptoms. Some symptoms include post-exertional fatigue/malaise, sleep problems/disturbances, joint and muscle pain, headaches, short-term memory loss, impaired concentration, hypersensitivity to light and sound, emotional overload, problems with dizziness and balance, recurrent flu-like symptoms, gastrointestinal problems and sensitivities to food, medications, odours or certain chemicals. It is common for patients to experience post-exertional fatigue/malaise, but the particular cluster of symptoms experienced can differ considerably from one person to another. Factors such as physical/cognitive activity, sleep, stress and mood may trigger or worsen symptoms. In this study, variables including physical/cognitive activity, sleep, stress, mood and fatigue are measured on a daily basis for period of 6-12 weeks via an electronic diary with an inbuilt accelerometer. Variables related to personally-relevant symptoms (e.g. body pain, headaches, dizziness) and potential triggers of symptoms (e.g. emotional distress, dehydration) are selected by participants at the start of the study and also added to the daily questionnaires.
Sponsors
The University of Queensland
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adults 18 years or older with a medical diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Individuals are not excluded on the basis of their gender, age or overall health status.
Exclusion criteria
Individuals under 18 years old. Individuals who have not received a medical diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Outcome results
None listed