None listed
Conditions
Brief summary
This study aims to explore the effect of green shell mussel (GSM: Perna canaliculus – Mytilidae) extract on pain levels and analgesic medication used of people with chronic hip and or knee joint pain. Participants will be blinded to group allocation (intervention group, control group) and will consume two capsules of either the GSM powder or the placebo (corn flour) daily for a period of 16 weeks. We hypothesise that the intervention group (receiving the GSM extract) will report lower pain levels and analgesic use, than the control group.
Interventions
GSM powder is a natural health supplement manufactured from sustainably farmed New Zealand Green Shell Mussels (Perna canaliculus). GSM powder is a rich source of naturally occurring bioactive compounds that may have anti-inflammatory, chondroprotective, and/or gastroprotective benefits. Each capsule contains 500 mg of GSM powder. Participants will consume two capsules (1000 mg) each morning with food, as per the manufacturer recommendations for 16 weeks.
Adherence will be monitored in two ways
GSM powder is a natural health supplement manufactured from sustainably farmed New Zealand Green Shell Mussels (Perna canaliculus). GSM powder is a rich source of naturally occurring bioactive compounds that may have anti-inflammatory, chondroprotective, and/or gastroprotective benefits. Each capsule contains 500 mg of GSM powder. Participants will consume two capsules (1000 mg) each morning with food, as per the manufacturer recommendations for 16 weeks. Adherence will be monitored in two ways. First, at the end of each week, participants will receive a message via their mobile phone asking "On how many days in the past week have consumed the capsules?" Second, at the end of the intervention participants will be asked to return any unused capsules.
Sponsors
Auckland University of Technology
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
• Have a three-month self-reported history of hip and/or knee joint pain • Report experiencing pain on more than 15 days in the past month • Live in the greater Auckland area • Own a smartphone, tablet or computer with access to the internet • Have sufficient English or Mandarin language to complete the assessment measures and participate in an interview.
Exclusion criteria
• Are, suspect they are, or intend to become pregnant during the course of the study • Breastfeeding • Have asthma, gout, liver disease, kidney disease or another medical condition which in the opinion of the researchers would influence the results of the study. • Have a known, or suspected seafood allergy • Are taking medication to thin the blood (i.e. aspirin or warfarin) • Have had, or are planning to have joint replacement surgery in the six months after enrolling in the study • Are already taking a GSM supplement • Have a fear of needles or of giving blood.
Outcome results
None listed