None listed
Conditions
Brief summary
This is a small study exploring the effect of the mode of delivery of salbutamol (inhaler vs. nebuliser) on the small airways of the lungs in patients with asthma. The effects of the two modes of delivery will be compared using measures of small airways disease from impulse oscillometry and multiple breath nitrogen washout. Asthma patients will attend two visits. At each visit, they will have these measures taken before and after bronchodilator therapy with salbutamol. At one visit, they will have nebulised salbutamol and at the other (in random) order, they will have salbutamol via metered-dose inhaler with spacer.
Interventions
One dose of inhaled salbutamol (1mg) given via metered-dose inhaler (with spacer) over 10 minutes and by nebuliser over 10 minutes on separate days and in random order. Treatment administered and observed by research staff during attendance at research unit. Washout between treatments a minimum of 24 hours.
Sponsors
University of Otago
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Physician-diagnosed asthma requiring a minimum of treatment with regular inhaled corticosteroid
Exclusion criteria
• Diagnosis of COPD, bronchiectasis, lung cancer. • Other co-morbidity likely to affect study participation. • Current smoker • Poor asthma control (see 2016 NZ asthma guidelines for definition) • Previous ICU admission for acute asthma
Outcome results
None listed