None listed
Conditions
Brief summary
Early detection of acute kidney injury in high-risk patients will enable clinicans to apply interventions to mitigate or prevent it early. Ten healthy adult volunteers will participate in this randomised crossover study. This study is evaluating the impact of hydration on urinary levels of two naturally occuring biomarkers with acute kidney injury. Participants will drink an additional 1000ml of water above their daily intake or fast from midnight for 12 hours. Urine samples will be tested at baseline, 12-hours and 24-hours to assess for changes in the urinary levels of these two biomarkers.
Interventions
Participants will be randomly allocated to 'increase their fluid intak'e by consuming 1000ml of water orally above their usual daily fluid intake or to 'fluid restrict' from mid-night for 12 hours. Following a washout of 4 days participants will complete the crossover intervention by either 'fluid restrict' or 'increase their fluid intake'. Study investigators will remind participants of their allocated study arm prior to and during the invervention period, however adherence is not actively moni
Participants will be randomly allocated to 'increase their fluid intak'e by consuming 1000ml of water orally above their usual daily fluid intake or to 'fluid restrict' from mid-night for 12 hours. Following a washout of 4 days participants will complete the crossover intervention by either 'fluid restrict' or 'increase their fluid intake'. Study investigators will remind participants of their allocated study arm prior to and during the invervention period, however adherence is not actively monitored.
Sponsors
Austin Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Aged 18 years or older Employed in the Department of Intensive Care, Austin Hospital (Heidelberg, Victoria, Australia) No known chronic kidney disease Not currently receiving diuretic treatment No known or suspected pregnancy participant provides written prior consent to participant
Exclusion criteria
None
Outcome results
None listed