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The effect of preoperative anxiety and mean platelet volume (MPV) on duration of induction and propofol consumption

The effect of preoperative anxiety and mean platelet volume (MPV) on duration of induction and propofol consumption of patient's undergoing cholecystectomy.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12618001750279
Acronym
APT (Anxiety Propofol Trial)
Enrollment
80
Registered
2018-10-24
Start date
2018-11-02
Completion date
2019-03-05
Last updated
2021-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Our primary aim is to evaluate the relationship between preoperative anxiety as assessed by Beck Anxiety Scale and mean platelet volume (MPV) as assessed by whole-blood assay. Our secondary aims are to evaluate the relationship between preoperative MPV and propofol induction time as assessed by observation and stopwatch and preoperative MPV and propofol consumption.as assessed by directly calculating the propofol volume infused by the perfusion device. One day before the operation the anxiety levels of the patients will be measured by Beck Anxiety Scale. The patients will be alllocated into two groups. The patients with axiety score lower than 8 points will be included in the first group (GRUP A, n=40).The patients with axiety score above 8 points will be included in the second group (GRUP NA, n=40). Then the propofol induction time and propofol consumption at the 30 minutes after induction of anesthesia will be measured for each patient.

Interventions

The preoperative anxiety levels of the patients will be assessed by Beck Anxiety Inventory at one day prior to surgery. The Beck Anxiety Inventory will be administered by an anaesthesist who is blind to study. The first 40 patients with a Beck score less than 8 will be enrolled into the first group(control group) and the first 40 patients with a Beck score equal to or greater than 8 will be enrolled into the second group. Propofol and remifentanyl infusions and intravenous rocuronium bromide w

The preoperative anxiety levels of the patients will be assessed by Beck Anxiety Inventory at one day prior to surgery. The Beck Anxiety Inventory will be administered by an anaesthesist who is blind to study. The first 40 patients with a Beck score less than 8 will be enrolled into the first group(control group) and the first 40 patients with a Beck score equal to or greater than 8 will be enrolled into the second group. Propofol and remifentanyl infusions and intravenous rocuronium bromide will be applied for induction and maintenance of anaesthesia. The time needed for entropy less than 60 will be recorded. Calculated total propofol consumption at the intraoperative 30th minute and time needed for eye opening will be recorded.

Sponsors

Ali Ihsan Uysal
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

1) 18-65 years old 2) ASA I-II 3) Patient's who will be operated for elective cholecystectomy

Exclusion criteria

1)Patient's who receive treatment for pyschiatric disease. 2)Patient's who have neurologic diease. 3)Pregnant or breastfeeding patients 4)Hypertension 5)Patient's who have metabolic and hematologic diease 6)Patient's who have received chronic medical theray for 2 months before the surgery. 7)Patient's who have chronic cardiac and respiratory diease 8)Patient's with a diease that possibly have an effect on mean platelet volume.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026