Effect of pressure in abdominal cavity on visceral blood flow in children

Effect of intraabdominal hypertension on splanchnic blood flow in children

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12618001716257

Enrollment

Registered

2018-10-17

Start date

2018-02-01

Completion date

2018-09-01

Last updated

2018-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Intraabdominal hypertension lead to multiple organ dysfunction syndrome (MODS). However, viscerae, such as intestines and liver are damaged first. Lot of experimental studies showed that an increase of intraabdominal pressure (IAP) more than 10 mm Hg leads to progressive splanchnic blood flow lowering and an IAP elevation above 20 mm Hg is followed by intestinal mucosa ischemia, bacterial translocation, sepsis and MODS. Clinical data on the relationship between IAP and splanchnic blood flow in children is lacking. Ninety four children who have undergone appendicular peritonitis surgery were enrolled in the study. IAP and splanchnic blood flow was measured 4 times per day in all children.

Interventions

Intraabdominal pressure, diameter and time-average mean blood flow velocity of the superior mesenteric artery and portal vein were measured 4 times per day for 7 days in all children who have undergone appendicular peritonitis surgery.

Eligibility

Sex/Gender

All

Age

1 Months to 18 Years

Healthy volunteers

Inclusion criteria

Children with peritonitis. Parents` consent.

Exclusion criteria

Lack of parents` consent

Outcome results