None listed
Conditions
Brief summary
In this single-centre study, two groups of women who were normal weight prior to a recent pregnancy will be recruited at 12 months post-partum: women who have already returned to their pre-pregnancy weight (group A) and those who remain 10% or more above their pre-pregnancy weight (group B). Women in group B will be prescribed a hypocaloric diet until they return to their pre-pregnancy weight. Hormones involved in appetite regulation and DNA methylation state in peripheral blood mononuclear cells in weight-relevant genes will be compared between groups. We hypothesise that in women who remain 10% or more above their pre-pregnancy weight 12 months post-partum (group B), the elevated weight is ‘defended’, and that compensatory changes in hormones involved in appetite regulation will occur when they lose weight.
Interventions
The study will be conducted at the Metabolic Disorders Centre, Department of Medicine, University of Melbourne (Austin Health). Women who are 10% or more above their pre-pregnancy weight (group B) will undergo a weight loss intervention. Guidance on following a hypocaloric diet will be provided face-to-face by a qualified dietitian, every 2 weeks until weight loss of at least 10% (to pre-pregnancy weight) is achieved. Each visit may take 10-45 mins, at the discretion of the dietitian according
The study will be conducted at the Metabolic Disorders Centre, Department of Medicine, University of Melbourne (Austin Health). Women who are 10% or more above their pre-pregnancy weight (group B) will undergo a weight loss intervention. Guidance on following a hypocaloric diet will be provided face-to-face by a qualified dietitian, every 2 weeks until weight loss of at least 10% (to pre-pregnancy weight) is achieved. Each visit may take 10-45 mins, at the discretion of the dietitian according to participant needs. The diet will be in accordance with the ‘Australian Guide to Healthy Eating’, aiming for loss of 1 kg per week until they return to their pre-pregnancy weight and if required, meal replacements (Optifast VLCD), will be added up to 2 times per day to facilitate weight loss. The maximum duration of the intervention will be 6 months.
Sponsors
Priya Sumithran
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Women with no previous history of obesity, who were normal weight (BMI 18.5-24.9 kg/m2) prior to a recent term (37+ weeks) singleton pregnancy, and are now 12 (± 2) months post-partum. Two groups of women will be recruited: those who have returned to within 2kg of their pre-pregnancy weight (group A), and those who remain 10% or more above pre-pregnancy weight (group B).
Exclusion criteria
Currently pregnant, smoking or taking medications which may affect weight
Outcome results
None listed