Survival of probiotic bacteria in the gut of Australian adults

Survival of Lactobacillus Casei Shirota in Australian adults gastrointestinal tract

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12618001607268

Enrollment

Registered

2018-09-27

Start date

2018-10-10

Completion date

2018-10-26

Last updated

2019-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Probiotics are defined as live microorganisms which when administered in adequate amount confer a health benefit on the host. The probiotic efficacy relies on their ability to survive in the digestive system and proliferate in the gut. The aim of this study is to investigate the survival of LcS in the intestine of healthy Australian adults after intake of fermented milk (Yakult). A single-arm, open-label study involving 25 otherwise healthy adults will examine the recovery of live culturable bacteria from faecal samples following 7 and 14 days of Yakult ingestion.

Interventions

Yakult Fermented Milk Beverage (containing Lactobacillus Casei Shirota 10^8 CFU/ml) - 65ml, once per day for 14 days. A daily diary will be used to assess compliance.

Study design

Allocation

Non-randomised trial

Primary purpose

Prevention

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

adults 18-40 years of age BMI: 18.5-29.9 daily bowel movement

Exclusion criteria

history of gastrointestinal disorder (diarrhea, constipation, IBS, IBD, abdominal pain) disordered requiring a modified diet (eg food allergy/intolerance) use of antibiotics, laxatives or anti diarrheal medications in the prior 30 days

Outcome results