None listed
Conditions
Brief summary
The aim of this pilot study is assess the efficacy of tranexamic acid in reducing post-operative pain, swelling and range of motion in patients undergoing arthroscopic meniscectomies. It is a blinded study in which participants are randomised to receive one intraoperative dose of either intravenous tranexamic acid or placebo (saline). Data collected is as follows: pain (0-10 scale), Lysholm knee score and Tegener activity score (to assess function), range of motion (measured by goniometer), suprapatellar and mid-calf circumferences (to assess swelling). Each of these data sets is collected pre-operatively (on the morning of surgery) and at three time points post-operatively (3, 14 and 30 days).
Interventions
Administration of tranexamic acid (one dose 1g in 10ml of 0.9% saline solution) or placebo (10ml 0.9% saline solution) intraoperatively. This is administered intravenously by the anaesthetist immediately post-induction.
Sponsors
Prof Gary Hooper
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients undergoing elective arthroscopic meniscectomy for meniscal tear(s)
Exclusion criteria
Previous reconstructive surgery on the same knee Known clotting disorders Known renal impairment Known allergy to tranexamic acid
Outcome results
None listed