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Identifying which patients will benefit from the UPLIFT program

Identifying responders and non-responders to the UPLIFT program for people with persistent low back pain: a prospective cohort study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12618001525279
Enrollment
246
Registered
2018-09-11
Start date
2018-05-29
Completion date
2019-06-26
Last updated
2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary aim of this study is to derive prediction models from baseline variables from the biological and psychosocial domains to identify responders and non-responders to the UPLIFT program. The secondary aim is to gain insight into what characteristics from the biological and psychosocial domains change following completion of the UPLIFT program and at 6 months follow-up. Considering the patient population referred to the program and the characteristics of the UPLIFT program, we hypothesise that the prediction model for success will include baseline variables such as high fear avoidance behaviours, low pain self-efficacy and matched treatment expectations. We hypothesise that the prediction model for non-success will include baseline variables such as high pain catastrophising, high perceived injustice and high scores on the disability and anxiety stress scale. We hypothesise that the derived prediction models will be significantly better at predicting responders and non-responders than the current 55%:45% ratio for treatment success versus non-success from pilot data.

Interventions

Name: The UPLIFT program. The UPLIFT program is an evidence-informed, biopsychosocial program for people with persistent lower back pain (LBP). UPLIFT is a 5-week, face to face group program, that combines cognitive therapy (e.g. pain neuroscience education) with exercise therapy (e.g. restoration of normal movement patterns, dynamic functional movements, global body exercise). Adults over 18 years who have been referred to the Gold Coast University Hospital (GCUH) Neurosurgical Screening Clinic

Name: The UPLIFT program. The UPLIFT program is an evidence-informed, biopsychosocial program for people with persistent lower back pain (LBP). UPLIFT is a 5-week, face to face group program, that combines cognitive therapy (e.g. pain neuroscience education) with exercise therapy (e.g. restoration of normal movement patterns, dynamic functional movements, global body exercise). Adults over 18 years who have been referred to the Gold Coast University Hospital (GCUH) Neurosurgical Screening Clinic with persistent (>6 months) LBP will be observed. Following consent to participate in the study, a research assistant will ask participants to complete 10 questionnaires. Participants will then commence the existing 5-week UPLIFT program consisting of five 90-minute sessions, held once per week at the GCUH physiotherapy outpatients department. The sessions are a combination of education and a graded exercise program conducted by two physiotherapists. Immediately upon completion of the program, and at six months, the research assistant (who will be blinded to program performance) will ask participants to complete the same questionnaires that were collected at baseline.

Sponsors

Kerrie Evans
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Inclusion criteria will be adults over 18 years who have been referred to the GCUH Neurosurgical Screening Clinic with persistent (>6 months) LBP, and who are able to read and write adequate English to comprehend education delivered within the program and complete written questionnaires.

Exclusion criteria

Exclusion criteria includes contraindications for exercise, recent spinal surgery (< 6 months), active inflammatory disorders, such as rheumatoid arthritis, and neurological conditions.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 20, 2026