The effect of single-dose beetroot juice on the blood pressure and cognition of healthy older versus younger adult

The effect of acute beetroot juice supplementation on the cardiovascular and cognition function of healthy older versus younger adult

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12618001466235

Acronym

TBJP (The Beetroot Juice Project)

Enrollment

Registered

2018-08-31

Start date

2016-08-05

Completion date

2017-10-24

Last updated

2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In today's society, rates of disease and age-related dysfunction continue to grow at a rapid speed. This has led to an increased interest in the use of food-based supplements such as beetroot juice. Beetroot juice contains nitrate and has been shown to reduce blood pressure, improve cardiovascular function and improve exercise performance. Furthermore, recent evidence has indicated that increased nitric oxide (the bio-active form of nitrate) may have effects on increased blood flow to the brain leading to improved cognition and mood in older adults. However, research in this area is limited and few studies have looked at the effects of beetroot juice when comparing younger and older adults. Overall aim: Therefore, the aim of this study is to examine the effects of acute nitrate supplementation, from beetroot juice as a breakfast food, on cognition, mood and cardiovascular responses in younger (18-30) versus older adults (50-70).

Interventions

Beetroot intervention: One bottle (150ml) of nitrate-rich beetroot juice (10.5 mmol nitrate) consumed acutely 2.25 hours prior to repeating testing and 2.5 hr prior to 30 minutes of walking exercise at moderate intensity (defined as a 3 on the Borg RPE 10-point scale). Intervention adherence will be controlled for by observing participants consume the drink in the laboratory Wash out period between trial was one week

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Between the ages of 18 - 30y or 50 - 70y Able to walk at moderate intensity for 30 min Healthy individuals

Exclusion criteria

Advanced/elite athletes (someone who trains more than four times per week constantly for their sport and competes at a high level) Taking blood pressure medication

Outcome results