None listed
Conditions
Brief summary
This phase 1 study will determine the feasibility of a technique that adapts imaging to patients breathing for use in radiotherapy treatments of lung cancer patients. Who is it for? You may be eligible to join this study if you are aged 18 years or above, and have been diagnosed with primary or secondary lung cancer. Study details Participants will undergo normal radiotherapy treatment with the addition of 5 imaging scans at the time of radiotherapy treatment on 2 days of treatment.
Interventions
This study involves the implementation of Respiratory Motion Guided (RMG) 4DCBCT for the first time on lung cancer patients. RMG-4DCBCT adapts the image acquisition as the patient’s breathing changes (i.e. if the patient breathes faster, imaging data is acquired faster). By adapting the acquisition to the moving patient, personalised images of a patients lungs are able to be acquired for radiotherapy treatments.
Additional equipment will be added to the radiotherapy treatment machine to allow
This study involves the implementation of Respiratory Motion Guided (RMG) 4DCBCT for the first time on lung cancer patients. RMG-4DCBCT adapts the image acquisition as the patient’s breathing changes (i.e. if the patient breathes faster, imaging data is acquired faster). By adapting the acquisition to the moving patient, personalised images of a patients lungs are able to be acquired for radiotherapy treatments. Additional equipment will be added to the radiotherapy treatment machine to allow for the RMG 4DCBCT scans. The images will be acquired on the day of treatment on two occasions (two separate days as close as possible to the beginning of the overall treatment) for 30 lung cancer patients. There is a total of 5 additional images per patient that will be acquired which means that the patient will be on the treatment couch for an additional 9 to 14 minutes in total. There is no other follow up required for the study following the acquisition of the images. The intervention will be administrated by the treating radiation therapists and members of the medical physics team.
Sponsors
University of Sydney
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
18 years or older. Have the ability to give informed consent A diagnosis of lung cancer with an indication for radiotherapy either curative or palliative Radiotherapy treatment involving the routine acquisition of CBCT for patient setup provided that 4DCBCT is to be acquired during the course of treatment. At least two radiotherapy fractions during the course of treatment.
Exclusion criteria
Pregnant women. Patients <18 years Patient who in the opinion of the treating physician could not tolerate the extra time on the treatment couch for two days of treatment.
Outcome results
None listed