None listed
Conditions
Brief summary
Antioxidants like Ubiquinol help protect our body from the stress of aging. However, they may not easily get to where the body needs them. Mitochondria-targeted antioxidants, like MitoQ, get into our muscle and potentially protect them from damage and may improve how our mitochondria work. The aim of this research is to compare the ability of MitoQ® to that of Qunol® Ubiquinol to be taken up by skeletal muscle and alter mitochondrial function and ROS production in aged males. A greater reduction of mitochondrial ROS production and enhancement of mitochondrial efficiency will indicate the more effective supplement and suggest greater potential to treat or prevent age-related functional decline. We hypothesise that MitoQ® and Qunol® Ubiquinol will alter mitochondrial function.
Interventions
Participants will be recruited using social media and newspapers, they will then be randomized to consume either MitoQ (1 capsule containing mitoquinol mesylate with a total dose of 20 mg of mitoquinol per day) or Ubiquinol (1 Softgel per day which contains 200 mg of CoQ10) in a double-blind manner for a period of 6 weeks for either supplement separated by a six week washout period and then 6 weeks for another supplement .
Participants will visit the laboratory on four occasions, with a muscle
Participants will be recruited using social media and newspapers, they will then be randomized to consume either MitoQ (1 capsule containing mitoquinol mesylate with a total dose of 20 mg of mitoquinol per day) or Ubiquinol (1 Softgel per day which contains 200 mg of CoQ10) in a double-blind manner for a period of 6 weeks for either supplement separated by a six week washout period and then 6 weeks for another supplement . Participants will visit the laboratory on four occasions, with a muscle biopsy, 24-hour urine and blood sample being collected at each visit, participants will also be assessed for muscle power/strength production using a dynamometer. High-resolution respirometry will be used to measure mitochondrial function and reactive oxygen species production. Markers of muscle and blood metabolic state and oxidative status will be measured is blood and muscle samples. MitoQ and Ubiquinol capsules will be provided by MitoQ. Participants will be asked to remain fasted from the night and provide a 3-day eating record before each visit. They will be asked to return drug tablets leftover after each intervention (a period of 6 weeks for each supplement). They will be also asked to wear a wristband for 5 days which tracks the level of physically active.
Sponsors
Faculty of Medical and Health Sciences, The University of Auckland
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
Male
Age
40 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Male 40-60 years of age BMI <32 Sedentary to moderately active (no running, cycling or sport training for more than 3 hours per week or, no more than two resistance training sessions per week) Healthy
Exclusion criteria
Chronic illness such as cancer, heart disease, diabetes and myopathy Smoker Have taken any antioxidant supplements within the previous two months
Outcome results
None listed