Determination of perioperative levels of cefazolin in paediatric cardiac surgical patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12618001183279

Enrollment

Registered

2018-07-17

Start date

2015-07-06

Completion date

2018-05-22

Last updated

2018-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The objective of this study was to determine the effect of age, prolonged bypass and deep hypothermia on perioperative levels of cefazolin in children undergoing cardiac surgery.

Interventions

Paediatric cardiac surgery requiring cardiopulmonary bypass with or without deep hypothermia (<25 degrees Celcius). Decision to use deep hypothermic arrest is at the surgeons discretion and is based on the surgical procedure to be undertaken. Commonly deep hypothermic arrest is used for Norwood procedures and procedures involving the aortic arch. Observation (blood tests) will be at eight timepoints during the operative period

Eligibility

Sex/Gender

All

Age

No minimum to 18 Years

Healthy volunteers

Inclusion criteria

Cardiac surgery involving cardiopulmonary bypass

Exclusion criteria

Pre-existing apparent infectious disease Renal failure (serum urea concentration > 6 mmol/l, serum creatinine > 100 µmol/l, anuria)

Outcome results