None listed
Conditions
Brief summary
This study will determine the prevalence and incidence of thiamine deficiency in patients admitted to the intensive care unit with sepsis and septic shock, and measure association with peak lactate concentrations at admission, and within 24, 48 and 72 hours of admission. As a pilot epidemiological study, this project will help inform future studies of the role of thiamine and other nutritional deficiencies in the pathogenesis and management of septic shock, and will provide useful data for hypothesis generation and calculation of sample size for future studies.
Interventions
Patients exposed to sepsis or septic shock will be monitored for thiamine deficiency. Therefore transketolase levels will be measured at 4 timepoints to determine (relative) thiamine deficiency. Also lactate levels will be observed in each patient, to review any relationship between thiamine deficiency and lactate levels.
Sponsors
Royal Adelaide Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Sepsis, defined as an infection complicated by organ dysfunction, identified as SOFA score greater than or equal to 2 or a change in SOFA greater than or equal to 2 point from baseline, OR Septic shock, defined as sepsis and persistent hypotension despite adequate fluid resuscitation, as seen by: 1. Vasopressors required to maintain MAP greater than or equal to 65 mmHg AND 2. Serum lactate level greater than 2 mmol/L
Exclusion criteria
<18 years of age; Pregnancy; Liver cirrhosis; Thiamine supplementation commenced, in the institution, prior to, or within 24 hours of ICU admission.
Outcome results
None listed