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The Relationship Between Spinal Anesthesia-Related Hypotension and Ultrasonography of Internal Juguler Vein in Cesarean Section

The Relationship Between Spinal Anesthesia-Related Hypotension and Ultrasonography of Internal Juguler Vein in Cesarean Section

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12618001067268
Enrollment
73
Registered
2018-06-26
Start date
2017-10-02
Completion date
2018-02-01
Last updated
2018-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Background:it has been shown that sonographic determination of the diameter of the inferior vena cava (IVC) is related to central venous pressure and other hemodynamic parameters describing the patient’s volume status. IVC measurements are not possible in 10-15% of patients because of large body size, excessive bowel gas, or large amounts of intrathoracic air. Since internal jugular vein (IJV) imaging does not require transthoracic echocardiography and is technically easier to perform than IVC visualization at pregnant women. This study investigated whether preoperative ultrasound IJV measurements could predict hypotension after spinal anesthesia in pregnant patients undergoing cesarean section. Methods:A prospective, observational study carried out in patients undergoing cesarean section. In 73 patients, older than 18 years and scheduled for elective cesarean section with spinal anesthesia were included in the study. Maximum diameter of the IJV (dIJVmax) and collapsibility index (CI) were measured preoperatively before spinal anesthesia. Hypotension was defined by a more than 20% decrease in systolic blood pressure from the baseline level or any recorded period of mean blood pressure lower than 60 mmHg.

Interventions

73 term pregnant women, older than 18 years undergoing elective cesarean section with spinal anesthesia were included the study. The exclusion criteria were high risk pregnancies who had chronic hypertension, preeclampsia, gestational diabetes, preterm pregnancy, pre-pregnancy obesity, or history of pregnancy complication and severe medical conditions such as pulmonary, liver and kidney disease. The women was then transferred to the operating theatre. Non-invasive blood pressure and heart rate w

73 term pregnant women, older than 18 years undergoing elective cesarean section with spinal anesthesia were included the study. The exclusion criteria were high risk pregnancies who had chronic hypertension, preeclampsia, gestational diabetes, preterm pregnancy, pre-pregnancy obesity, or history of pregnancy complication and severe medical conditions such as pulmonary, liver and kidney disease. The women was then transferred to the operating theatre. Non-invasive blood pressure and heart rate was applied with the woman in the supine position with an estimated 15° left lateral table tilt to avoid aortocaval compression by the uterus. After a stabilisation interval of 3–5 min, baseline systolic blood pressure (SBP) and mean blood pressure (MBP) were recorded. We used the non-invasive oscillometric method. After measurements, the antero-posterior internal jugular vein (IJV) diameter was measured using M-mode during a respiratory cycle. In order to avoid changes in vein diameter unrelated to respiratory variation, gentle pressure by the Ultrasonograhy (USG) probe was used to collapse the IJV in order to distinguish it from the carotid artery, then the pressure was relieved to the USG probe-skin interface and attention was given to avoid influence of probe compression on IJV dimensions during the USG examination. Moreover, in order to avoid interference of probeto- vein angle, the IJV evaluation was performed by positioning the probe perpendicular to the skin and oriented orthogonally to the IJV short-axis diameter. Ultrasound measurements of IJV diameter with respiration, which include maximum diameter of the IJV (dIJVmax) at the end of expiration during spontaneous respiration and collapsibility index (CI), have been recorded. The IJV CI (%) was calculated as CI = (dIJVmax – dIJVmin)/dIJVmax and was expressed as percentage. All measurements were made by a single author to eliminate interobserver variability. Episodes of hypotension in the period after spinal anesthesia were defined by a more than 20% decrease in SBP from the baseline level or any recorded period of MBP lower than 60 mmHg. The MBP reading before IJV USG was defined as baseline. The duration of observation of each participant was 2 hour.

Sponsors

Derya Karasu
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

- 18 years older - elective cesarean section under spinal anesthesia - whose physical status is consistent with ASA II class -gestational age must be >37 weeks

Exclusion criteria

-neurological disease -preeclampsia, diabetes mellitus, infection on the surgical site, -disorders associated with bleeding/ clotting, severe agitation, -non-cooperation, rejection of regional anesthesia, - known fetal abnormality, placenta previa, history of ablatio placentae, risk for growth retardation and meconium aspiration; pathology that may affect the acid-base balance, antepartum hemorrhage, - severe medical conditions such as pulmonary, liver and kidney disease.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026