None listed
Conditions
Brief summary
The purpose of study is to assess amd compare the efficacy and side effects of carbamazipine, oxcarbazipine amd baclofen in patients with trigeminal neuralgia.
Interventions
A double blinded randomised control trial will be conducted in oral and maxillofacial surgery department of Islamic International Dental College Islamabad. There will be three groups. An independent researcher "X" will do randomisation. He will prescribe one of three drugs for 1 month ( carbamazipine upto 1200 mg, oxcarbazipine upto 1200 mg or baclofen upto 30 mg). He will prescribe one of three drugs daily for one month. Doses may vary.Patient will self administer the drug in form of oral table
A double blinded randomised control trial will be conducted in oral and maxillofacial surgery department of Islamic International Dental College Islamabad. There will be three groups. An independent researcher "X" will do randomisation. He will prescribe one of three drugs for 1 month ( carbamazipine upto 1200 mg, oxcarbazipine upto 1200 mg or baclofen upto 30 mg). He will prescribe one of three drugs daily for one month. Doses may vary.Patient will self administer the drug in form of oral tablet. Other investigators Dr. A or B ( unaware of the drug prescribed by Dr. X) will take patients VAS before the commencement of treatment and will take VAS score again after three months. Every participant will receive only one drug To evaluate the side effects of drugs and monitor adherence to drug, record will be taken before starting and after 1 month of therapy. Heamotological and hepatic enzymes will be evaluated by lab test.
Sponsors
Mohsin Fazal
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
a. Patients with trigeminal neuralgia. b. Patients above 18 years c. Patients who have sufficient cognitive function
Exclusion criteria
a. Patient already taking any other kind of medication for the treatment of neuralgia b. Patients who have undergone surgical procedure for management of Trigeminal Neuralgia. c. Patients who have hypersensitivity to carbamazepine, oxcarbazepine or baclofen. d. Patients with acute or chronic liver or renal failure. e. Patients who were on drugs that may affect cognitive function e.g. psychiatric drugs including tricyclic antidepressants. f. Patients who were not willing for follow up.
Outcome results
None listed