None listed
Conditions
Brief summary
Many people report digestive problems with dairy products. This may be due to the sugar in milk, lactose, which causes intolerance in many people. However, the proteins and fats in milk also affect how it is digested, and how well people can tolerate dairy products. Sheep milk has different protein, fat, and micronutrient content than cow milk, and behaves differently during food processing. The different proteins and fats in sheep milk may be easier to tolerate for some people. For example the A1 version beta-casein is thought to cause digestive discomfort; this is found in typical cow milk but not sheep milk. Similarly, the medium chain fatty acids rich in sheep milk are easily digested and absorbed. Although these differences mean that sheep milk is likely to be digested differently, so far this hasn’t yet been studied. Women will be recruited who self-report digestive issues with cow milk and will be provided, in a double blind manner, cow and sheep milk on separate occasions. The digestive response, tolerance to lactose, and appearance of digested products in the blood will be measured to assess the characteristics of digestion and metabolism between sheep and cow milk.
Interventions
Volume matched whole milk (650ml), to be consumed only once on two different occasions separated by at least one week washout period between beverages. Beverages will be consumed within 15 minutes in full in the presence of the researchers to confirm compliance. Milk will be consumed after a overnight fast (8 hours, water allowed), with no other food or beverage consumed for the duration 4 hour intervention. Milks::
1. Whole sheep milk
2. Whole cow milk
Sponsors
University of Auckland
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
Female 20-40 years BMI 18-28 kg/m2 Self-described dairy intolerant No history of gastrointestinal disease or metabolic disease
Exclusion criteria
Have an allergy to milk. Are diagnosed with gastrointestinal disease (i.e. celiac, Crohn’s, colitis, etc.) or pre-existing metabolic disease. Are currently taking medications expected to interfere with normal digestive or metabolic processes including proton pump inhibitors, laxatives, antibiotics (within last 3 months), prebiotics etc. Have a medical history precluding a healthy state: history of myocardial infarction, angina, stroke, cancer or pre-existing diabetes, self-reported alcohol intake exceeding a moderate intake (>28 units per week).
Outcome results
None listed