None listed
Conditions
Brief summary
The aim of this study is to compare the concentration of fentanyl between maternal and cord blood in women administered intranasal (IN) or subcutaneous (SC) fentanyl for labour analgesia. A prospective observational study will be conducted at Gawler Health Service. Fentanyl is routinely offered (via the intranasal or subcutaneous routes) to women requesting pain relief in labour at Gawler Health Service. Maternal and cord blood samples will be collected at the time of birth to determine the plasma concentration of fentanyl in order to assess the relative exposure of the neonate to the maternal administration.. Maternal and cord blood samples will be collected in heparin tubes, within 30 minutes of each other and refrigerated at 4°C. Tthe samples will then be processed at SA Pathology where they will be centrifuged at 3000 rev min-1 for 10 minutes, the plasma removed and frozen at -20°C until the time of assay.
Interventions
The aim of this study is to compare the concentration of fentanyl between maternal and cord blood in women administered intranasal (IN) or subcutaneous (SC) fentanyl for labour analgesia. Corresponding 3mL maternal and 1-3mL umbilical cord blood samples will be collected from women administered intrapartum fentanyl and their neonates. Duration of observation includes the time from first fentanyl dose administered in labour to 30 minutes post birth.
Sponsors
The University of South Australia
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Age: 18- 40 years Have no known allergy to fentanyl Women who have received either intranasal or subcutaneous fentanyl in labour Viable fetus in a vertex presentation Vaginal birth at term (37-42 weeks)
Exclusion criteria
Pre-term birth Multiple birth Operative birth Have a known allergy to fentanyl
Outcome results
None listed