None listed
Conditions
Brief summary
We hypothesise that preoperative coadministration of ibuprofen and pregabalin combination is resulted better pain control than preoperative placebo or same dose of sole ibuprofen The objective of this study was to compare the efficacy of pregabalin and intravenous ibuprofen with regard to pain management and analgesic consumption after third molar surgery. Materials and methods: This was a prospective, randomized, controlled, double-blind study. Eighty patients who had planned for surgical extraction of impacted third molars were included in the study. The treatment groups included the following: (Group 1) premedicated with oral placebo and intravenous (IV) placebo, (Group 2) premedicated with oral placebo and 400 mg IV Ibuprofen, (Group 3) premedicated with 75 mg oral pregabalin and 400 mg IV ibuprofen, and (Group 4) premedicated with 150 mg oral pregabalin and 400 mg IV ibuprofen. The primary outcome measured was postoperative pain levels; secondary outcomes included the nonnarcotic analgesic requirement and the first rescue analgesic request time. The ratio of male/female participants, age, side effects, surgery difficulty, and duration of surgery were also evaluated.
Interventions
Single-Dose Oral Pregabalin and Intravenous Ibuprofen Combination Administration before oral surgery. The treatment groups included the following: (Group 1) premedicated with oral placebo and intravenous (IV) placebo, (Group 2) premedicated with oral placebo and 400 mg IV Ibuprofen, (Group 3) premedicated with 75 mg oral pregabalin and 400 mg IV ibuprofen, and (Group 4) premedicated with 150 mg oral pregabalin and 400 mg IV ibuprofen.
Oral pregabalin (75 or 150 mg) (Lyrica; Pfizer, Inc., New Yor
Single-Dose Oral Pregabalin and Intravenous Ibuprofen Combination Administration before oral surgery. The treatment groups included the following: (Group 1) premedicated with oral placebo and intravenous (IV) placebo, (Group 2) premedicated with oral placebo and 400 mg IV Ibuprofen, (Group 3) premedicated with 75 mg oral pregabalin and 400 mg IV ibuprofen, and (Group 4) premedicated with 150 mg oral pregabalin and 400 mg IV ibuprofen. Oral pregabalin (75 or 150 mg) (Lyrica; Pfizer, Inc., New York, NY) and oral placebo (using similar looking cornstarch capsules) were administered to the corresponding treatment groups one hour before surgery. Intravenous ibuprofen (400 mg) (Intrafen; Gen Pharmaceuticals, Istanbul, Turkey) and intravenous placebo (sterile saline solution) were administered via intravenous infusion 30 minutes before surgery The medications were administered by a nurse who supervised by the director of the department, from the oral and maxillofacial surgery department.
Sponsors
Ataturk University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 24 Years
Healthy volunteers
No
Inclusion criteria
presence of soft tissue-impacted third molars, or partially or fully bony impacted mandibular third molars in a Pell-Gregory class II-B position that required surgical removal
Exclusion criteria
patient refusal, age outside of 18-24 years, ASA scores of III or IV, renal or hepatic failure, allergy to the study medication or related drugs, immune compromised status, psychological disorders, bleeding disorders, gastrointestinal system complaints, epilepsy or other neurological disorders, pregnancy or those breastfeeding, medication use less than 10 days before the surgery, preoperative inflammation, and lactose intolerance. Patients whose impacted teeth were exposed to the oral cavity before surgery and those, in which the duration of the surgical procedure exceeded 30 minutes, were also excluded.
Outcome results
None listed