Sugammadex Effects on Children's Awakening from Adenotonsillectomy Surgery

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Safe and adequate return of airway reflexes and cognitive functions during recovery period after general anaesthesia is important especially in short-term paediatric surgeries. The most stressful experience for children during perioperative period is anaesthesia induction but awakening in foreign environment without parents is similarly stressful. We purposed to search if sugammadex causes or increases emergence agitation and laryngospasm due to fast termination of the neuromuscular blockage and quick awakening. Ninety ASA 1 children between 3-15 years will be included the study randomized and prospectively and will be premedicated with midazolam0.5 mg/kg orally. Standard monitoring procedures per the American Society of Anaesthesiologists and train of four (TOF)monitoring will be performed. For induction sevoflurane %8 and N2O-O2 %50 or in children which have vascular access propofol 2-3 mg/kg, fentanyl 1 µg/kg, lidocaine 1 mg/kg and rocuronium 0.6 mg/kg will be administered. Anesthesia will be maintained with sevoflurane and N2O-O2. Dexamethasone 0.1 mg/kg, paracetamol 15 mg/kg and ondansetron 0.1 mg/kg will be applied. When the operation finish, inhalation anaesthetics will be stopped and when TOF is %25, neostigmine 50 µg/kg and atropine 0.20 µg/kg(n=45) or sugammadex 2 mg/kg will be applied randomly (double-blinded). Time between TOF %25-90, total anaesthesia, operation and eye-opening times will be recorded. All will be evaluated with agitation scale (AS) and paediatric anaesthesia emergence delirium (PAED) scale in the recovery room. We will call agitated which had AS>3 and PAED>=10.

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