None listed
Conditions
Brief summary
Low flow anesthesia is widely used in developed countries. There is suspicion about the safety of low-flow anesthesia in anesthesiologists in Turkey, We wanted to compare low-flow anesthesia and high-flow anesthesia in obese and normal-weight patients. to prove that low-flow anesthesia is safe even in laparoscopic surgery in obese patients.
Interventions
All patients will be using the same brand anesthesia device (dräger perseus A500) and the same brand sodalime.
We will perform monitorization (Electrocardiography, SpO2, noninvasive systolic diastolic blood pressure) in our normal routine protocol before the surgery.
2-3 mg / kg propofol, 1-2 µg / kg fentanyl, 0.6 mg / kg rocuronium , 1 mg/kg lidocaine will be administered intravenously during induction of anesthesia. After 2 minutes the patient will be intubated. We will use desfluran
All patients will be using the same brand anesthesia device (dräger perseus A500) and the same brand sodalime. We will perform monitorization (Electrocardiography, SpO2, noninvasive systolic diastolic blood pressure) in our normal routine protocol before the surgery. 2-3 mg / kg propofol, 1-2 µg / kg fentanyl, 0.6 mg / kg rocuronium , 1 mg/kg lidocaine will be administered intravenously during induction of anesthesia. After 2 minutes the patient will be intubated. We will use desflurane as inhaler anesthetic; nitrogen protoxide will not be used. ARM1: NORMAL WEIGHT, LOW FLOW GROUP. The fresh gas flow will be adjusted to 2 lt/ min (FiO2: 80%), desflurane 12% until the minimum alveolar concentration (MAC) reached to 1 after intubation in normal weight patients (body mass index greater than or equal to 18 and less than 25) . After reaching MAC 1, fresh gas flow will be decreased to 0,5 lt/min and desflurane will be adjusted as MAC 1. FiO2 will continue as 80%. 15 minutes ago before the surgery has finished, we will close desflurane. ARM2: OBESE, LOW FLOW GROUP. The fresh gas flow will be adjusted to 2 lt/ min (FiO2: 80%), desflurane 12% until the minimum alveolar concentration (MAC) reached to 1 after intubation in obese patients (body mass index greater than or equal to 30) . After reaching MAC 1, fresh gas flow will be decreased to 0,5 lt/min and desflurane will be adjusted as MAC 1. FiO2 will continue as 80%. 15 minutes ago before the surgery has finished, we will close desflurane. ARM3: NORMAL WEIGHT, HIGH FLOW GROUP. The fresh gas flow will be adjusted to 2 lt/ min (FiO2: 50%), desflurane 12% until the minimum alveolar concentration (MAC) reached to 1 after intubation in normal weight patients. After reaching MAC 1, the fresh gas flow will continue at 2 lt/min (FiO2:50%) and desflurane will be adjusted as MAC 1. ARM4: OBESE, HIGH FLOW GROUP. The fresh gas flow will be adjusted to 2 lt/ min (FiO2: 50%), desflurane 12% until the minimum alveolar concentration (MAC) reached to 1 after intubation in obese patients. After reaching MAC 1, the fresh gas flow will continue at 2 lt/min (FiO2:50%) and desflurane will be adjusted as MAC 1. All patients will be followed by an experienced anesthesiologist for at least 4 years. The mean duration of surgery is 60 minutes.
Sponsors
Mehmet Tercan.
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
patients who are undergoing laparoscopic cholecystectomy surgery obese patients, normal weight patients
Exclusion criteria
smokers, ASA 3-4 patients, overweight patients
Outcome results
None listed