None listed
Conditions
Brief summary
It has been postulated that satiety and cognitive function are dependent upon the concentration of circulating blood glucose. The primary purpose of the study therefore, is to test whether measures of satiety and cognition are effected by differing concentrations of circulating blood glucose concentrations. To generate differences in blood glucose concentration, beverages sweetened with 50g of either sucrose or isomaltulose were developed. In order to match the beverages for sweetness, a small amount of sucralose was added to the isomaltulose beverage. A triangle taste test was undertaken in six people with the result that the two beverages were indistinguishable from one another. The blood glucose response to the test beverages was undertaken in a subset of 12 of the 75 participants. The tests of satiety and cognition were conducted in the afternoon. The order in which participants received the test beverages was randomised to each person. Each participant consumed both of the test drinks in a crossover design with a washout of at least two days. Standard test methodology was used to test for subjective and objective satiety. During the test period of three hours, a film was shown in three half hour time-slots with a 20 minute interval between each showing. During the three intervals, a standard word recall test was administered and participants answered questions relating to the section of film that had just been screened. One trailmaking test was administered at the end of each session. The people administering the tests and the participants were unaware of which beverage had just been consumed (double-blinding). Data analysis was undertaken by a biostatistician blinded to order of treatment. The study hypothesis was that a more stable blood glucose concentration over time, represented by the isomaltulose treatment, would result in greater satiety and a better cognitive performance.
Interventions
This will be a double-blind crossover trial in which 75 healthy adults will ingest a 500ml sparkling water beverage containing either 50g of sucrose or a beverage containing a mix of 50g isomaltulose with 45mg sucralose. The order in which participants receive the beverages will be randomised to each person. There will be a minimum 2 day washout between beverages. Prior to the intervention, participants will be given a standard lunch of sushi and water. Participants will ingest the intervention
This will be a double-blind crossover trial in which 75 healthy adults will ingest a 500ml sparkling water beverage containing either 50g of sucrose or a beverage containing a mix of 50g isomaltulose with 45mg sucralose. The order in which participants receive the beverages will be randomised to each person. There will be a minimum 2 day washout between beverages. Prior to the intervention, participants will be given a standard lunch of sushi and water. Participants will ingest the intervention beverages within 15 minutes 1.5hr following lunch. Eating lunch and subsequent assessment of satiety and tests of cognition will be under the supervision of the study investigators.
Sponsors
University of Otago
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy adults
Exclusion criteria
Intolerance to isomaltulose or sucralose
Outcome results
None listed