None listed
Conditions
Brief summary
The diagnosis of sleep-disordered breathing (SDB) is associated with increased incidence and prevalence of atrial fibrillation (AF). However, nightly SDB-severity rather than the categorical diagnosis of SDB may directly influence AF-risk during the respective day thereby creating a dynamic substrate for AF. While chronic structural alterations induced by SDB have been already described in AF patients with SDB, the role of night-to-night variability in SDB severity is unclear and clinical evidence for a dynamic AF substrate in patients related to nightly SDB severity is lacking. By simultaneous long-term night-by-night SDB and AF monitoring, we examine the dynamic intra-individual relationship between daily SDB-severity and risk of incident AF during the respective day.
Interventions
Observational Study:
Daily data on atrial fibrillation burden and average respiratory disturbance index (RDI, sleep apnea status)) were extracted from a sample of Reply 200 or Kora 100 DR pacemakers in 72 patients with a mean follow-up per patient of 21±7 weeks. Nightly RDI within each patient was grouped into quartiles, with the highest quartile representing the 25% of nights with most severe SDB for that particular patient. A daily cumulative AF-burden of >5 mins, >1 hr and >12 hrs per day we
Observational Study: Daily data on atrial fibrillation burden and average respiratory disturbance index (RDI, sleep apnea status)) were extracted from a sample of Reply 200 or Kora 100 DR pacemakers in 72 patients with a mean follow-up per patient of 21±7 weeks. Nightly RDI within each patient was grouped into quartiles, with the highest quartile representing the 25% of nights with most severe SDB for that particular patient. A daily cumulative AF-burden of >5 mins, >1 hr and >12 hrs per day were the outcome variables.
Sponsors
Center for Heart Rhythm Disorders.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Implanted dual-chamber pacemakers Reply 200 or Kora 100 DR (LivaNova, France) with implemented SDB monitoring (SAM) measuring a respiratory disturbance index (RDI)
Exclusion criteria
- <1 month of follow-up since implant - SDB monitoring (SAM) turned off - >10% invalid RDI - unreliable mode switch estimates due to atrial under sensing - persistent AF throughout the recording
Outcome results
None listed