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The benefit of sampling the lactate levels in umbilical cord artery after birth to provide information to doctors and nurses about care in labour and improve future practice.

Introduction of universal cord lactate sampling and correlation with neonatal outcomes in a low resource setting

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12618000689279
Enrollment
994
Registered
2018-04-27
Start date
2014-03-03
Completion date
2014-11-12
Last updated
2018-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This project aims to use sampling the umbilical cord after birth for lactate levels (a measure of physiological stress) as a feedback tool to improve care in labour. It will combine this tool with training of clinicians in the physiology of fetal heart rate in labour and interpretation of abnormal appearing fetal heart rates. By comparing the lactate with the care given in a particular labour, clinicians can use the process of case reflection to change practice for future cases, improving neonatal outcomes over time. In addition to this, the lactate samples will allow us to correlate results with neonatal outcomes and compare these in different groups of women; HIV compared with non HIV and term compared with pre-term It will be an example of how we can use assistance and technology from a developed country and introduce it into a developing country to improve medical outcomes. The hand held lactate meters are portable and inexpensive, yet can provide objective feedback to health care workers on labour outcomes. This direct evidence of intrapartum care should be able to stimulate the continued ongoing audit of labour outcomes well beyond the conduct of this study, such that the local care providers can maintain this audit tool outside of a research setting

Interventions

All midwives and registrars in the unit underwent a training course in fetal physiology, lactate physiology and cardiotocograph (CTG) interpretation, conducted by the primary researcher (EA). The course consisted of a pre-test, a series of didactic lectures, interactive application of knowledge with CTG examples, and a post-test. The course was an intensive half a day course. The pre-test consisted of 20 multiple choice questions. Then 3 hour long lectures were given; on fetal physiology, fetal

All midwives and registrars in the unit underwent a training course in fetal physiology, lactate physiology and cardiotocograph (CTG) interpretation, conducted by the primary researcher (EA). The course consisted of a pre-test, a series of didactic lectures, interactive application of knowledge with CTG examples, and a post-test. The course was an intensive half a day course. The pre-test consisted of 20 multiple choice questions. Then 3 hour long lectures were given; on fetal physiology, fetal acid base status, and CTG pattern recognition. A 36 questionairre post test was then delivered. It was a requirement of the unit that all doctors and midwifes complete the training. Subsequently umbilical artery lactate sampling occurred, with the results made immediately available to the clinicians managing the intrapartum care of women in the labour ward. Lactate samples were obtained by (after maternal consent was obtained): the umbilical cord was clamped and cut within one minute of birth. A small arterial blood sample (<0.5uL) was then taken from a double clamped segment of the remaining umbilical cord, prior to delivery of the placenta. The lactate level was measured (mmol/L) on a Roche Accutrend PlusTM© hand-held lactate meter (Rotkreuz, Switzerland). The coefficient of variation (CV) for this lactate meter is 1.8-3%. Furthermore, all lactate samples obtained in the previous 24 hours were reviewed at the daily morning labour ward meetings of all medical staff (interns, registrars, and consultants), and twice weekly, an in-depth review of interesting or challenging cases was facilitated by the primary researcher (EA). Daily reviews involved correlating CTG interpretation pre-delivery with neonatal outcomes, including the UA lactate. During the two study periods, basic data on all deliveries (regardless of recruitment to the study) were collected, including number of deliveries, mode of deliveries, and admissions to the neonatal nursery (all levels).

Sponsors

Dr Emma Allanson
Lead SponsorIndividual

Study design

Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Prevention
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

All women attending Kalafong Hospital with a view to a planned vaginal birth. Women will receive routine intrapartum care defined by the institutions policies.

Exclusion criteria

- Women unable to give consent - Cases with planned cord blood collection for stem cell banking

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026