None listed
Conditions
Brief summary
This study aims to evaluate the effectiveness of a 6- week comprehensive supervised pre-surgical exercise program in prostate cancer patients scheduled for prostatectomy. Who is it for? You may be eligible to join this study if you are a male aged between 45 and 80 years of age and have been diagnosed with localised prostate cancer with at least seven weeks to until scheduled surgery date. Study details Study participants will be allocated by chance to one of the two groups. The first group will receive a 6- week comprehensive supervised pre-surgical exercise program consisting of progressive resistance and aerobic exercise. The second group will receive usual care during the pre-surgery period along with information on performing exercises on the trunk stabilising muscles similar to the exercise intervention. This group will be provided with an option to partake in the home-exercise intervention of 6 weeks prior to surgery. Testing will be conducted at baseline, pre-surgery and 6 weeks post- surgery (6PS). Testing will involve, strength and aerobic tests, a body scan, questionnaires and a 24-hr pad test. In addition, a 24-hr pad test will be undertaken after discharge from hospital and at the 12 weeks after surgery. This research is a critical step in a series of studies required to determine the most effective and efficient ways to maximize prostate cancer patient health and therefore lay the foundation for future research.
Interventions
A randomised 2 group study design will be used to evaluate and compare the effectiveness of a 6-week supervised gym-based exercise program to a home-based program undertaken prior to surgery, with assessments being conducted at the Edith Cowan University Exercise Medicine Research Institute (EMRI). The gym-based exercise group (Ex) will be provided with the exercise training undertaken thrice weekly in an exercise setting and the home-based exercise group (HB) will be provided with an exercise information booklet and information on a 6-week home-based exercise program with weekly telephone calls. Assessments will be conducted at baseline, pre-surgery, and 6-weeks post-surgery. In addition, a 24-hr pad test will be undertaken after patients are discharged from hospital and have had their urinary catheter removed and subsequently at 6 and 12-weeks post-surgery. Patients will be invited to participate by their attending urologists from the Perth Urology Clinic. This replicates an existing collaboration between EMRI and the urologists at the participating clinic. Information about the program will be provided and those that express interest will be contacted by the research team. Ex group: Exercise sessions will be ~60 minutes, commencing with a warm-up consisting of a moderate level of aerobic exercise [~60% heart rate maximum (HRmax)]. Resistance-training regime targeting upper- and lower-limb exercises (chest press, leg press, seated row, leg curls, leg extension, bicep curls, and calf raises) will be conducted. Progression of resistance exercise will follow guidelines previously outlined: week 1 – 2 (two sets 12 repetition maximum (RM)), week 3 (three sets of 10 RM), week 4 – 5 (three sets of 8 RM), and week 6 (four sets of 6 RM). This will be followed by 10 minutes of exercises focusing on the trunk stabilising muscles which include three sets of three different exercises [planks (anterior abdominals), the reverse bridge on a Swiss ball (back extensors) and side planks (oblique abdominals)] with a rest of 30 seconds between sets. Finally, the session will conclude with 20 minutes of aerobic exercise at 60 – 80% (intensity) of the estimated HRmax (220 – age in years) followed by a cool down. Participants will be asked to complete further aerobic sessions to meet the 150 minutes per week aerobic guidelines which would be monitored by a participant diary. All sessions will be supervised by an accredited exercise physiologist to ensure safety and adherence.
Sponsors
Study design
Eligibility
Inclusion criteria
Inclusion criteria 1. Localised prostate cancer. 2. Have at least seven weeks between diagnosis of cancer and surgery date. 3. No acute illness, musculoskeletal, cardiovascular or neurological disorder that could place the participant at risk of injury or illness resulting from the exercise. 4. Ability to walk 400m unassisted and undertake upper- and lower-body exercise. 5. Not be performing regular exercise defined as undertaking structured aerobic or resistance training two or more times per week within the past 3 months. 6. Be able to read and speak English.
Exclusion criteria
1) metastasised cancer patient 2) any illness and inability to walk 400m unassisted 3) patient undertaking structured resistance exercise