None listed
Conditions
Brief summary
Prostate cancer is still a common disease worldwide. It can lead to death. Many ways to for treating this disease do exist. This study aimed to compare two ways of treatment of this disease especially when it's advanced or late. Men aged 55 to 75 years were included in this study. All of them were having prostate cancer at a late stage. All patients had underwent surgical removal of both testes. However, some of the patients in the study were given a specific drug for Prostate cancer as additional treatment way. Both groups of men were followed for their response to the surgery alone or to the surgery with medicine to discover how they differ in their improvement state. The main goal was to know whether it is useful to give the patients medical treatment beside the surgery to control their disease. The men in the study were real patients and they were offered the necessary treatment after taking their consent. No major serious bad events were expected to occur for them as a result of these treatments apart from the effect of their cancer. About 60 men were included in the study which was done in Iraq at Basrah Teaching Hospital in Basrah city. The study started in 2012 and continued for about 5 years. However, for each individual patient the period of involvement in the study was about two years.
Interventions
Patients with advanced prostate cancer were randomized into two groups after being subjected to surgical castration by bilateral simple orchidectomy . The duration of surgery was about 30 minutes. Group I was followed up for disease progression after orchidectomy alone.Group II patients also had underwent bilateral simple orchidectomy but additionally they were given oral flutamide 250 mg tablets three times daily after meals for up to two years and were followed up. Bilateral simple Orchi
Patients with advanced prostate cancer were randomized into two groups after being subjected to surgical castration by bilateral simple orchidectomy . The duration of surgery was about 30 minutes. Group I was followed up for disease progression after orchidectomy alone.Group II patients also had underwent bilateral simple orchidectomy but additionally they were given oral flutamide 250 mg tablets three times daily after meals for up to two years and were followed up. Bilateral simple Orchidectomy for both groups was done by scrotal approach under spinal anesthesia . The patients were asked to return the drug tablet to ensure adherence to the intervention.The follow up period was up to two years following orchidectomy for both groups.
Sponsors
Basrah university
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
55 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Patients with advanced prostate cancer
Exclusion criteria
patients with local disease or severe co-morbidities .
Outcome results
None listed