None listed
Conditions
Brief summary
Purpose: To search platelet activation via detecting three important platelet activation parameters; Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and Plateletcrit (PCT) in patients with central retinal vein occlusion (CRVO) in comparison to those in healthy adults as controls. Design: A prospective case control study Participants and Controls: 30 patients within the CRVO (Group 1) and 30 age-and sex-matched healthy controls will included into the study (Group 2). Methods: All patients and control subjects will undergo complete ophthalmologic evaluation. MPV, PDW, and PCT were measured in the studied groups. Main Outcome Measures: Alterations in platelet activation parameters. The mean level of MPV PDW and PCT value in Group 1 and in Group 2 will determined.
Interventions
Blood sampled will be collected in patients with acute cenral retinal vein occlusion (CRVO). Platellet activation will be assessed. Patients with CRVO will be treated with conventional therapy. The observation period commences at the same time as treatment. (No multiple timepoints). Duration of observation is 1 month.
Sponsors
Ankara Ulucanlar Eye Education and research hospital.
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
We included the CRVO patients with posterior segment involvement.. The diagnosis of CRVO will reached using fundus photography, fluorescein angiography, and optical coherence tomography. Patients and healthy volunteers that were matched for age and gender included in this study
Exclusion criteria
Patients and healthy volunteers who were on any kind of medication including corticosteroid and immunosuppressive therapy, who had smoking (smoke more than 1 cigarette per day) and drinking ( >1 standard drink per week) habits, or who had history of systemic and ocular disease will not included in the study
Outcome results
None listed