None listed
Conditions
Brief summary
Background: A growing interest has been focused on the association between chronic endometritis (CE), and often asymptomatic inflammation of the endometrial lining and recurrent miscarriage (RM). Cicinelli et al, demonstrated that fluid hysteroscopy is a reliable technique for diagnosing chronic endometritis (CE) based on demonstrating specific signs such as micro polyps, stromal edema, and focal or diffuse hyperemia. Objectives: This prospective study designed to evaluate the relation between chronic endometritis, and recurrent miscarriage. Analysis of the hospital records over the last 5 years from January 2012 to January 2017 to identify women with unexplained RM, after approval of the Obstetrics and Gynecology department of Ahmadi hospital. Inclusion criteria includes; women who will give consent, >20-40 years, with 3 or more miscarriages before 22 weeks’ gestation. Studied women will go under diagnostic hysteroscopy in the follicular phase of the menstrual cycle. During, hysteroscopies the uterine cavity will be explored through the panoramic view, with thorough evaluation of the endometrial mucosa. Chronic endometritis defined as demonstration of micro-polyps that fluctuate in the cavity, stromal edema, and focal or diffuse hyperemia. The surgeon will take an endometrial biopsy from studied women with evidence of chronic endometritis during hysteroscopic examination for histological examination. Studied women diagnosed with chronic endometritis (CE) during hysteroscopy will scheduled for endometrial biopsy in the follicular phase of the subsequent cycle, The endometrial biopsy will be cultured for the common infectious pathogens which include; Neisseria gonorrhea, Chlamydia trachomatis, Mycoplasma species, Ureaplasma urealyticum, and yeast at the endometrial levels.
Interventions
Analysis of the hospital records over the last 5 years from January 2012 to January 2017 to identify women with unexplained recurrent miscarriage, after approval of the Obstetrics and Gynecology department of Ahmadi hospital. Inclusion criteria includes; women who will give consent, >20-40 years, with 3 or more miscarriages before 22 weeks’ gestation.
Studied women will go under diagnostic hysteroscopy in the follicular phase of the menstrual cycle, and endometrial biopsy for histological exami
Analysis of the hospital records over the last 5 years from January 2012 to January 2017 to identify women with unexplained recurrent miscarriage, after approval of the Obstetrics and Gynecology department of Ahmadi hospital. Inclusion criteria includes; women who will give consent, >20-40 years, with 3 or more miscarriages before 22 weeks’ gestation. Studied women will go under diagnostic hysteroscopy in the follicular phase of the menstrual cycle, and endometrial biopsy for histological examination. Studied women diagnosed with chronic endometritis during hysteroscopy will scheduled for endometrial biopsy in the follicular phase of the subsequent cycle, The endometrial biopsy will be cultured for the common infectious pathogens which include; Neisseria gonorrhea, Chlamydia trachomatis, Mycoplasma species, Ureaplasma urealyticum, and yeast at the endometrial levels. Outcome measures; the relation between chronic endometritis and recurrent miscarriage. Duration of observation for each studied woman will be 5 weeks,
Sponsors
Department of Obstetrics and Gynecology, Ahmadi hospital, Kuwait.
Study design
Allocation
Non-randomised trial
Primary purpose
Diagnosis
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
Patients and methods: Analysis of the hospital records over the last 5 years from January 2012 to January 2017 to identify women with unexplained recurrent miscarriage, after approval of the Obstetrics and Gynecology department. Inclusion criteria includes; women who will give consent, >20-40 years, with 3 or more miscarriages before 22 weeks’ gestation.
Exclusion criteria
Exclusion criteria includes; family history of RM, uterine abnormalities, hormonal or metabolic disorders, severe male factor infertility, previous surgery for myoma and/or endometriosis, clinical or ultrasound diagnosis of endometriosis, known clinical autoimmune disease, anti-phospholipid syndrome (APS), thrombophilic condition requiring anticoagulant therapy, and unwilling to give informed consent.
Outcome results
None listed