None listed
Conditions
Brief summary
Intensive care unit treated sepsis, severe sepsis and septic shock are associated with several long term complications from different organs systems. There is evidence of accelerated impairment of cognitive functions when repeated cognitive testing is performed before and after a sepsis period. However it is not known if the cognitive impairment eventually is reflected in an increased frequency of dementia in an age-mixed ICU population. For this reason we wish to explore the incidence of dementia and identify its risk factors in sepsis survivors. This will be done in the Swedish intensive care cohort defined as all patients with an ICU episode with severe sepsis or septic shock in the Swedish intensive care registry from 2005 to 2016. Diagnosis of dementia will be identified in the Swedish National board of health Patient registry. Patients without a diagnosis of dementia before ICU will be followed from first sepsis to 2016 for a new dementia diagnosis and compared to all ICU/treated patients without severe sepsis or septic shock.
Interventions
The exposure is Intensive Care Unit (ICU) care for sepsis, severe sepsis or septic shock (sepsis) in the Swedish ICU-registry (SIR) between the years 2005 and 2016. Patients will be followed until december 31:st 2016.
Sponsors
Uppsala university, the institution of surgical sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
First episode, per patient, of ICU-care with a diagnosis of sepsis in the SIR.
Exclusion criteria
Age below 18 years of age. Already included with an earlier episode of ICU-treated sepsis. Loss to follow-up: emigration or protected identity. Dementia prior to, or diagnosed during, ICU episode.
Outcome results
None listed