None listed
Conditions
Brief summary
Atropine eye drops are known to affect pupil reactions and the ability of the eyes to focus on near objects. This study will quantify the effects of different concentrations of atropine eye drops on these ocular structures.
Interventions
Arm 1:
Drug Name: Atropine Sulphate
Dose: 1 drop of 0.01% atropine sulphate eye drops in each eye
Duration: Single Dose
Mode of administration: Topical eye drop instilled directly by researcher
Arm 2:
Drug Name: Atropine Sulphate
Dose: 1 drop of 0.02% atropine sulphate eye drops in each eye
Duration: Single Dose
Mode of administration: Topical eye drop instilled directly by researcher
Arm 3:
Drug Name: Atropine Sulphate
Dose: 1 drop of 0.05% atropine sulphate eye drops in each eye
Duration
Arm 1: Drug Name: Atropine Sulphate Dose: 1 drop of 0.01% atropine sulphate eye drops in each eye Duration: Single Dose Mode of administration: Topical eye drop instilled directly by researcher Arm 2: Drug Name: Atropine Sulphate Dose: 1 drop of 0.02% atropine sulphate eye drops in each eye Duration: Single Dose Mode of administration: Topical eye drop instilled directly by researcher Arm 3: Drug Name: Atropine Sulphate Dose: 1 drop of 0.05% atropine sulphate eye drops in each eye Duration: Single Dose Mode of administration: Topical eye drop instilled directly by researcher
Sponsors
UNSW Sydney
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1) Normal general and ocular health 2) Adults aged 18-40 years 3) No allergy to atropine or preservatives 4) No history or risk of glaucoma
Exclusion criteria
1) Recent atropine eye drop use prior to enrolment 2) Any eye diseases including inflammation, infection or allergy 3) History of allergic reaction to eye medications 4) Risk of glaucoma 5) Currently using any eye medications or systemic monoamine oxidase inhibitors (MAOIs) 6) Women who are pregnant, planning to become pregnant or breastfeeding
Outcome results
None listed