None listed
Conditions
Brief summary
There has been an increase in the number of discharges against medical advice for endoscopic procedures in recent times and given this, patients could be at significant risk when discharging unsupervised from the clinical environment. As many patients now receive propofol as the sole agent for sedational anaesthesia for endoscopic procedures, we decided to conduct a study that assesses the cognitive and motor function of patients before and after propofol only anaesthesia in this clinical setting. We did this by using two computer tests called the SART and SOPT, which are validated to a BAL of 0.05 and were completed by patients prior to and again one hour after their procedure. We also conduced the same battery of tests on volunteers not receiving propofol to assess for any learning bias obtained by participants completing the test at one hour intervals. From this study, we aim to determine the level of cognitive impairment 1 hour post propofol only anaesthesia for endoscopic procedures, if any, which may help with discharge planning for patients in the future.
Interventions
Patients receiving propofol only anaesthesia for endoscopic procedures are administered two computer programs called the "self ordered pointing test" (SOPT) and the "sustained attention to response task" (SART). These tests were administered 30 minutes prior to the patients procedure and again, 1 hour post emergence from the patients procedure and patients were observed for an estimated 1.5 hours in total from the first to last assessment. In the SOPT test, the participant is presented number of images and she/he is asked to pick one. On the next screen the order of the images is scrambled and the subject is asked to pick a different image amongst the number of images which were presented to a participant on the previous screen. This repeats until all images are selected. This test measures working memory, verbal learning, visuospatial ability, and select aspects of executive functioning. The SART test is a computer-based task designed to measure a person's ability to withhold responses to infrequent and unpredictable stimuli during a period of rapid and rhythmic responding to frequent stimuli. The participant was flashed a sequence of disordered numbers between 1-9 and was asked to press the space bar in response to being flashed the number 3. The SART and SOPT have been studied heavily in the past with subjects exposed to alcohol and validated to a BAL of <0.05.
Sponsors
Eligibility
Inclusion criteria
Any ages welcomed >18y Patients must have received propofol only anaesthesia for endoscopy
Exclusion criteria
Prior history of dementia or cognitive impairment Recent use of alcohol/benzodiazepines Non English speakers