None listed
Conditions
Brief summary
The human microbiome is known to have a major impact on human health. Pregnancy is a unique state where enormous hormonal, metabolic, immune and cardiovascular changes occur. We will assess the changes occurring in the microbiome in association to dietary changes at stages throughout this critical period of a mother and child’s life in response to these changes. Samples of the microbiome during pregnancy (faecal, oral, and vaginal) and after birth (placental, breastmilk, meconium) will be assessed to determine a link between pregnancy outcome and disease. We will study each participant during her pregnancy and for 1 year post partum.
Interventions
1. Collection of Saliva, vaginal swab and stool sample from mother and baby. These samples will be processed, stored and analysed to determine the microbiome composition and diversity. An online dietary intake survey will also be completed every 6 months.
2. Assessments will be performed three times (in each trimester) during pregnancy, at birth, 6 weeks, 6 months and 12 months post partum
3. Total duration will be the length of pregnancy and for 12 months post-partum
Sponsors
St George Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
- Less than 12 weeks gestation
Exclusion criteria
- Under the age of 18 years. - People highly dependent on medical care by virtue of major preexisting mental and/or physical disabilities - Woman requiring interpreter services for either her usual care or to understand the study information will not be recruited - Planning to have a home birth.
Outcome results
None listed