None listed
Conditions
Brief summary
This study investigates the effect of doxycycline, a commonly used antibiotic, on reducing heart muscle injury when given before angioplasty and stenting of the coronary artery is performed. Patients will be assessed with cardiac magnetic resonance imaging (the current gold-standard test) to determine the amount of heart muscle damage and heart function. Doxycycline is an inexpensive antibiotic that has numerous other beneficial effects, which might make it useful as an additional therapy for the emergent treatment of patients presenting with heart attacks. This medication has been used safely in adults for various infectious disease and has been tested in critically ill patients and found to be safe. If doxycycline can help lessen heart muscle injury and preserve heart function, it could change the way heart attacks are currently treated. Furthermore, it will be a very cost-effective add-on therapy.
Interventions
Administration of intravenous Doxycycline 100mg in 100mL in addition to standards of care prior to establishing reperfusion of STEMI patients followed by oral Doxycycline of 100mg twice per day for seven days
Sponsors
Alfred Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
- Consecutive men aged greater than 18 years and women aged greater than 55, or women less than 55 years and have no possibility of being pregnant; and - Presenting within 12 hours of the onset of chest pain and with ECG findings of anterior or inferior ST-segment elevation or new left bundle branch block and for whom the clinical decision has been made to treat with PPCI; and - Occlusion of the culprit related artery (TIMI grade 0 or TIMI grade 1) on coronary angiography, proximal and/or mid left anterior descending artery (LAD), or proximal dominant left circumflex (LCx) or dominant right coronary artery (RCA)
Exclusion criteria
• Historical or Electrocardiograph (ECG) evidence of previous myocardial infarction; or • Patients with prior coronary artery bypass grafting (CABG); or • Previous revascularisation procedure where this procedure (PCI) was performed in the LAD/RCA; or • Known pre-existing left ventricular dysfunction; or • Known or suspected pregnancy; or • Patients presenting with cardiac arrest or cardiogenic shock; or • Patients undergoing rescue PCI for failed thrombolysis; or • Patients with left main coronary artery stenosis of such severity that after PCI of their culprit lesion (LAD/RCA) they are likely to require coronary artery bypass graft (CABG) within the time course of the study period (6 months). • Known allergy to tetracyclines; • Contraindications to CMR
Outcome results
None listed