Feasibility of a single-prong nasal cannula to deliver Nasal High Flow therapy in healthy volunteers

Optiflow Uno - a single prong nasal interface to deliver Nasal High Flow The participant will spend two nights in the Sleep Lab. On one night the participant will receive the Optiflow Uno (intervention) and on the other night the Optiflow+ (control); the order that each device is received will be randomized. The AIRVO 2 will be used to generate the high flows and to heat and humidify the respiratory gas. The flows delivered via the Optiflow Uno will range between 0 to 30 L/min of heated and humidified room air. There are two parts to the study; 1) changes in breathing in response to Nasal High Flow therapy during both wakefulness and sleep and 2) perception of the Nasal High Flow therapy as delivered by the device. Part 1: Breathing will be measured using respiratory inductance plethysmography during periods of receiving no therapy (baseline) and Nasal High Flow therapy (intervention) when awake and asleep. During sleep, breathing responses to Nasal High Flow therapy will be obtained during non-REM sleep. During part 1, breathing will be measured during different flow rates of Nasal High Flow (0 to 30 L/min); each flow rate will be applied for a maximum of 30 minutes at a time. Part 2: Once breathing responses are obtained, the flow rate of the Nasal High Flow will be set at the level that the subject went to sleep with, and is comfortable with, for the rest of the night. The subject is free to wake at any time and to remove the nasal interface at any time. At the time of waking the subject will be asked to fill in questionnaires and answer questions relating to the experience of the nasal interface. The study will be conducted in the Fisher and Paykel Sleep Lab located in Auckland, NZ and will be performed by Fisher and Paykel Healthcare Scientists