None listed
Conditions
Brief summary
The MOBILISE study is a randomised control trial comparing antibiotic administration via a small pump with a continuous antibiotic infusion to the traditional method of a hospital pump and pole with multiple daily dosing of antibiotics.
Interventions
An ambulatory pump for a continuous infusion of antibiotics, called Ambit pump, will be used to administer the prescribed antibiotic. The Ambit pump is a small device, about the size and weight of a TV remote, that will be carried in a provided bum bag. The duration and type of antibiotic treatment will be dependent on the participant's ailment and that chosen by the treating medical team. For the purposes of this study the potential treatment minimum period will be 24 hours and the maximum peri
An ambulatory pump for a continuous infusion of antibiotics, called Ambit pump, will be used to administer the prescribed antibiotic. The Ambit pump is a small device, about the size and weight of a TV remote, that will be carried in a provided bum bag. The duration and type of antibiotic treatment will be dependent on the participant's ailment and that chosen by the treating medical team. For the purposes of this study the potential treatment minimum period will be 24 hours and the maximum period of treatment will be 7 days.
Sponsors
University of Queensland Centre for Clinical Research
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age greater than 18 years; 2. Have a PICC line in-situ with a line dedicated to only be used for antibiotic administration; 3. Require an antibiotic that is considered stable for administration by either a 12 or 24 hour infusion (i.e. benzylpenicillin, flucloxacillin, cephazolin, ceftazidime, cefepime, ceftolazone-tazobactam, lincomycin, piperacillin-tazobactam and vancomycin); 4. The antibiotic selection is definitive based on the patient’s condition or microbiological results and not empirical, 5. One lumen of the PICC line is dedicated to antibiotic administration only 6. The patient is able to mobilize at baseline i.e. not wheel chair bound or bed bound or attached to monitors/medical equipment/receiving dressings that do not allow patient movement around the hospital and are at least 48 hours post their last surgical procedure. The patient is expected to mobilise independently at discharge from hospital; 7. Do not reside at a nursing home; 8. The patient has the ability to provide informed consent to enter the study.
Exclusion criteria
1. The patient will be removed from the study if less than 24 hours of antibiotics are received while enrolled in the study; 2. The patient is unwilling to wear the GENEactiv device on their ankle with the ankle strap; 3. The patient is unable or unwilling to look after the pump and antibiotic bag adequately; 4. The patient is unable to wear the accelerometer on their ankle for reasons such as wounds, heart failure, dressings and amputation 5. The patient is unwilling to complete the exit patient survey regarding their satisfaction with the pump and antibiotic administration. 6. Planned surgery in the week post expected enrolment onto the trial. 7. The patient is expected to be discharged from the acute hospital setting within the first 24 hours post enrolment to the study.
Outcome results
None listed