Predictors of clinical outcomes in patients admitted with influenza and whether troponin levels during hospital admission predicts clinical outcomes in patients with influenza?

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Seasonal influenza is responsible for significant morbidity and mortality around the world. It may result in 200,000 to 500,00 deaths per year and numbers can be higher during pandemics. The frequency of myocardial involvement in influenza is variable with rates up to 10% having being reported in literature and depends upon the methods used to detect myocardial involvement. It is unclear how common asymptomatic cardiac involvement of influenza is although it has been reported as anywhere from 0 to 53% of cases. Although influenza is known to be associated with adverse cardiovascular outcomes but limited studies have studied relationship between troponin levels during hospital admission and clinical outcomes and it is unknown whether increased troponin levels can be used to predict clinical outcomes in these patients. The primary objective of this study will be to determine variables associated with adverse clinical outcomes in hospitalized patient admitted with influenza and other objective will be to determine whether troponin levels during admission correlates with length of hospital stay, complications during hospital admission and readmissions within 1 month and 6 months following discharge. This study will involve only retrospective collection of data of all confirmed cases of influenza admitted in Flinders Medical Centre and Royal Adelaide Hospital between January 2014 and October 2017. The anticipated benefits are possibility of finding new variables, which can predict clinical outcomes in patients admitted with influenza and thus may help in directing strategies to high-risk patients in future.