None listed
Conditions
Brief summary
Aim: To compare the effect of total knee arthroplasty (TDA) pain and early-range of knee motion tolerance on abductor canal block wiht levobupivacaine (ACB-L) and periarticular levobupivacaine infiltration (PAI-L). Materials and Methods: The study will plan as a prospective randomized clinical trial. Eighty patients aged 40-85 years who undergo periarticular levobupivacain infiltration (Group PAI-L; n = 39) and adductor canal block with levatorobupivacaine (Group ACB-L; n = 40) for elective unilateral total knee arthroplasty will includ in the study. Pain scores during both rest and passive-active physical therapy at the postoperative 30 minutes, 2, 6, 12, 24, 36 and 48th hours postoperatively will assess using the Visual Pain Scale (VAS), and postoperative 1 and 2th day at maximum flexion and extension angle grades achieved in the knee at 2 and 6th weeks, 3-meter walking test results at 24 and 48th hours postoperatively, and total consumed morphine quantities will record.
Interventions
Anesthesia and surgical technique The patient will admitte to the operating room without any premedication to avoid unwanted sedation, and all patients will subject to spinal anesthesia using a 22 gauge spinal needle and spinal bupivacaine (15 mg) after standard monitoring. During the operation, fluid treatment will perform with 6-9 mL kg h-1 with 0.9% NaCl. All operations will perform by the same surgical team using the same technique and a pneumatic tourniquet. In the operation, midline skin incision, limited medial parapatellar arthrotomy and traditional consecutive medial release will observe. The anterior and posterior ligaments will remove from the knee. Distal femoral and proximal tibia cuts will perform using intramedullary and extramedullary alignment guides, respectively. The balances of the medial / lateral ligaments and flexion / extension spaces will adjuste to confirm the absence of abnormal findings on valgus / varus stress tests, the ability to achieve full knee extensiveness, and whether medial / lateral laxity was absent or untried. Femoral and tibial components in all patients will fix with cement. Patellar implant wil not appy in any patient. Group ACB-L After spinal anesthesia, a ultrasoun-guided (10-18 MHz) linear probe in aseptic conditions will place midway between the inguinal ligament and the medial condyle of the knee in a supine position, with the knee slightly twisted and with the leg outstretched (frog leg position). Ultrasonographic image of the saphenous nerve will capture in the adductor channel laterally of the femoral artery beneath the sartorius muscle, shifting to the prop medial-lateral line. Local skin anesthesia will perform with 1% lidocaine. In addition to ultrasound guidance, a peripheral nerve stimulator will use. After the quadriceps motor movement (0.5 mA, 0.1 ms) with the neurostimulator would observed and negative aspiration, 20 ml of 0.25% levobupivacaine will apply to the nerve sheath with 20 gauge, 100 mm, sloped, teflon coated, unipolar needle. Local anesthetic extension will visualize with ultrasonography in the adductor duct. Group PAI-L 20 mL of 0.9% sodium chloride solution with 20 ml of 0.25% levobupivicaine will prepare in operation table when cement is cured. A total of 40 mL 0.125 mg levobupivacaine will infiltrate into the periosteum of the posterior capsule, femur and tibia, medial and lateral to the joint capsule, quadriceps tendon and vastus medialis oblique, patellar tendon and dermal epidermal junctions. Postoperative protocol All patients will treate with 50 mg IV dexketoprofen in the recovery room. Patient-controlled analgesia device (PCA) will insert (IV morphine bolus dose 1 mg, locking time 10 minutes 4 hour limit 500 mg) will record at 24 and 48th hours of morphine consumption. Antibiotic prophylaxis will continue with 3×1 gr Cefosin for 24 hours. The patients will give dexketoprofen every 12 hours and 1 g paracetamol tablet every 8 hours until discharge. 20 mg IV metachloropropamide will give for nausea and vomiting. The patient will usually treat with a knee immobilizer between 12 and 24 hours until quadriceps muscle function will restore. Physical therapy will initiate 24 hours after surgery. He continuous passive motion machine (CPM) in the room in the orthopedic department will start with an initial setting of 45 degrees. CPM will be used in patients on the 2nd day postoperatively and in 2 hour periods. While not using the machine, the patient will apply active flexion-extension movements for the self-knee. Clinical Evaluation Sociodemographic and clinical data such as age, sex, weight, height, body mass index, ASA, operation side, operation time, tourniquet time will record. Pain levels during rest and active physical therapy during the preoperative period, postoperative 30 minutes, 2 6, 12, 24, 36 and 48th hours with the visual pain scale (VAS), and the time of first analgesic requirement will record. Postoperative maximal range of knee flexion and extension at 1, 2, 7th days, 2 and 6th weeks will also record. In addition, 3-meter walking data during preoperative period, post-operative 24 and 48th hours will record.
Sponsors
Study design
Eligibility
Inclusion criteria
After obtaining participants’written informed consent, 80 patients, 40-85 years who were American Society of Anesthesiologists (ASA) I-III undergoing single TKA for degenerative joint disease will enroll in the clinic study.
Exclusion criteria
ASA IV-V, over 40 years old or over 85 years old, chronic pain syndrome or neuropathic pain, over 5 mg / day oral morphine or equivalent opioids, morbid obese, coagulation-deficient, upper gastrointestinal hemorrhage or perforation story with , patients who can not walk without help due to an out - of - knee disease, patients who were allergic to medications used in the study will exclude from the study.