Comparison of Arterial Vasoreactivity and Arterial Stiffness Between Obesity Hypoventilation Syndrome and Obese Obstructive Sleep Apnoea

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12618000402246

Acronym

OHS-CVS Study

Enrollment

Registered

2018-03-20

Start date

2018-04-09

Completion date

2021-02-26

Last updated

2018-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The OHS population have higher cardiovascular morbidity and mortality than the OSA population despite correcting for age and weight. This study aims to elucidate some of the factors contributing to the discrepancy in cardiovascular health between the two studied populations.

Interventions

Conditions observed: Obesity hypoventilation syndrome (obese, daytime hypercapnia with paCO2 =/> 45mmHg) Duration of observation: At one point in time (at enrolment) i.e. cross-sectional study Usually would be at diagnosis of condition

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

OHS group: • BMI>30kg.m-2 • Daytime respiratory failure with a PaCO2>45mmHg (OHS group) • pH is in the normal range at admission (7.35-7.45) • Willingness to provide informed consent OSA group: • BMI>30kg.m-2 • AHI>30 • Willingness to provide informed consent

Exclusion criteria

OHS group: • Presence of any other condition that may contribute to hypoventilation • Uncontrolled medical or psychiatric conditions • Recent myocardial infarction (6weeks) • Any pre-existing CVA/TIA • Any decompensated heart failure • Long term positive airway pressure therapy prior to enrolment • Women lactating or pregnant • Not proficient in English • Inability to provide informed consent OSA group: • Presence of hypercapnia (paCO2 > 45mmHg) • Uncontrolled medical or psychiatric conditions • Recent myocardial infarction (6weeks) • Any pre-existing CVA/TIA • Any decompensated heart failure • Long term positive airway pressure therapy prior to enrolment • Women lactating or pregnant • Not proficient in English • Inability to provide informed consent

Outcome results