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Clinical Evaluation and Comparison of the Effectiveness of Platelet Rich Fibrin versus Buccal Advancement Flap Surgery for the Immediate Closure of Acute Oroantral Communications

Comparison of the Clinical Outcomes (pain, analgesics doses taken, swelling) of PRF application versus Buccal Advancement Flap Surgery for the closure of acute oroantral communications (OACs).

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12618000399291
Enrollment
36
Registered
2018-03-20
Start date
2011-11-25
Completion date
2017-06-28
Last updated
2018-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study was to compare the clinical outcomes of buccal advancement flap surgery with PRF application in the closure of acute oroantral communications (AOACs). In 36 patients, following the extractions of maxillary posterior teeth, AOACs which were larger than 3mm diameter were detected. In group A, 21 patients were treated with the use of PRF and in group B, buccal advancement flap was used in 15 patients. Baseline variables such as pain, the number of analgesics taken and swelling were assessed preoperatively. These were also examined on postoperative days 1, 2, 3, 7, and patients were seen again on the third week but no measurements were done. Only visual check up were done intraorally to control extracted socket healing and photos of that region were taken.

Interventions

In 36 patients, following the extractions of maxillary posterior teeth, Acute oroantral communications (OACs) which were larger than 3mm diameter were detected. In group A, 21 patients were treated with the use of platelet rich fibrin (PRF) and in group B, buccal advancement flap was used in 15 patients. 1st intervention (group A): Two PRF clots were used for the treatment of acute OACs. Blood samples of each patient were taken directly into 2 x 10 mL glass-coated plastic tubes (excluding antico

In 36 patients, following the extractions of maxillary posterior teeth, Acute oroantral communications (OACs) which were larger than 3mm diameter were detected. In group A, 21 patients were treated with the use of platelet rich fibrin (PRF) and in group B, buccal advancement flap was used in 15 patients. 1st intervention (group A): Two PRF clots were used for the treatment of acute OACs. Blood samples of each patient were taken directly into 2 x 10 mL glass-coated plastic tubes (excluding anticoagulant, and immediately centrifuged at 3000 rpm for 10 min (Elektro-mag, M415P, Istanbul). The platelet-poor plasma was separated from middle part (PRF) that accumulated at the top of the tube and collected the PRF from roughly 2 mm below its’ contact point with the red corpuscles to include any remaining platelets.Then, two PRF clots were gently placed into the extraction cavity and sutured to avoid them from escaping to the sinus and for stabilization. 2nd intervention (group B): Buccal advancement flap was used to close acute oroantral communications. The extraction socket was closed by sliding the buccal flap over the socket and suturing the flap to the undermined palatal mucosa. All interventions were performed by oral and maxillofacial surgeon.

Sponsors

Near East University, Faculty of Dentistry Department of Oral and Maxillofaical Surgery
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Healthy volunteers
No

Inclusion criteria

Detection of acute oroantral communication (perforation) larger than 3 mm following the extraction of maxillary molar tooth. The volunteers who had neither systemic diseases nor signs of sinus disease. Also, they had no smoking or drinking habits.

Exclusion criteria

Patients who had chronic or acute systemic diseases.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026