None listed
Conditions
Brief summary
The aim of this study is to assess the influence of faster and slower fluid challenge administration rate on macrohemodynamic variables and microcircirculation in the population of surgical and septic patients. Our hypothesis was that faster fluid challenge leads to bigger macrohemodynamic effects but harms microcirculation more than slower one.
Interventions
Intravenous administration of Hartmann´s solution in dose of 5 ml per kg of patient´s body weight to test patient´s hemodynamic response in different rate (fluid challenge) - either fast (5-10minutes - Arm 1/Intervention) or slow (25-30 minutes - Arm 2/Control). The fluid challenge will be performed by the treating physician (anesthesiologist or intensive care physician) during anesthesia (within 30 minutes after induction) or at the intensive care unit (within 48 hours of sepsis onset/ ICU adm
Intravenous administration of Hartmann´s solution in dose of 5 ml per kg of patient´s body weight to test patient´s hemodynamic response in different rate (fluid challenge) - either fast (5-10minutes - Arm 1/Intervention) or slow (25-30 minutes - Arm 2/Control). The fluid challenge will be performed by the treating physician (anesthesiologist or intensive care physician) during anesthesia (within 30 minutes after induction) or at the intensive care unit (within 48 hours of sepsis onset/ ICU admission).
Sponsors
Charles University Hospital Plzen
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
all patients undergoing scheduled lumbar spine surgery in general anesthesia or patients with sepsis/septic shock admitted to the intensive care unit within first 48 hours after diagnosis
Exclusion criteria
Patients with pathology in the oral cavity (bleeding, neoplasia), previously diagnosed systemic microangiopathy and atrial fibrillation were excluded from the trial
Outcome results
None listed