None listed
Conditions
Brief summary
This project is a world first and vital step towards developing an effective falls prevention intervention for the large numbers of Australian stroke survivors. Fifty people aged over 50 years old with a diagnosis of first ever stroke will be recruited and monitored for 12 months for falls, falls injury, serum levels of vitamin D, parathyroid hormone, highly sensitive C-reactive protein and triglycerides, and strength, balance and walking in people after stroke. This project will produce detailed information and understanding about the link between vitamin D and falls in stroke survivors, an essential step in enabling the development and evaluation of effective falls prevention interventions (e.g. Vitamin D supplementation) for stroke survivors. The outcomes will enable clinicians and researchers to develop evidence-based interventions that will be implemented and tested in future projects in order to reduce falls and falls injury in older people after stroke and to improve their quality of life. The data produced by this project will mean that future phases of this work will attract government and other funding, such as National Health and Medical Research Funding. Overall impact will be measured by the development of a successful intervention that reduces falls in people with stroke. Aims 1. Describe the trajectory of vitamin D levels in people in the first twelve months after stroke. 2. Describe the relationship between vitamin D levels, physical function (strength and balance), falls and injury in people in the twelve months after stroke. 3. Determine the relationship between other related biochemical markers (parathyroid hormone, C reactive protein and triglycerides) and falls in the twelve months after stroke. Research Questions: 1. What is the trajectory of vitamin D levels in the first 12 months after stroke? 2. What is the current use of vitamin D supplementation in first 12 months after stroke? 3. Is vitamin D deficiency associated with physical function and falls in the twelve months following stroke? 4. Is vitamin D deficiency associated with injury severity following a fall in the twelve months after a stroke? 5. What is the relationship between other biochemical markers (parathyroid hormone, highly sensitive C-reactive protein and triglycerides) and falls in stroke survivors in the first twelve months?
Interventions
The research program involves prospective observational study of vitamin D and other biochemical marker levels in the first twelve months after stroke, with falls, injury and physical function data also collected prospectively. The aims are to describe vitamin D and other biomarker levels in the first twelve months after stroke, To evaluate the associations between vitamin D, falls, injury and functional outcomes, including strength, balance and walking, and to determine existing levels of vitam
The research program involves prospective observational study of vitamin D and other biochemical marker levels in the first twelve months after stroke, with falls, injury and physical function data also collected prospectively. The aims are to describe vitamin D and other biomarker levels in the first twelve months after stroke, To evaluate the associations between vitamin D, falls, injury and functional outcomes, including strength, balance and walking, and to determine existing levels of vitamin D supplementation in people with stroke.
Sponsors
National Ageing Research Institute
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
(1) aged at least 50 years, and for women post menopausal, (2) admitted to hospital with first ever ischaemic stroke, confirmed by imaging preferably MRI (if MRI contraindicated, then evidence of stroke on CT), (3) able to give informed consent or a person responsible providing informed consent, (4) previously (prior to stroke) active and able to walk independently with/without aid in the community, (5) previously (prior to stroke) residing in the community or a retirement village, and (6) are likely to be discharged to non residential aged care accommodation on discharge from hospital.
Exclusion criteria
People will be excluded if they are • Haemorrhagic stroke, • receiving palliative care, and/or • have kidney or liver conditions affecting vitamin D levels. If female the participant can not be pre-menopausal.
Outcome results
None listed