Are point-of-care albumin/creatinine measurements accurate in critically ill patients?

Are point-of-care urine albumin/creatinine measurements accurate in critically ill patients when compared to laboratory analysis.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12618000341224

Enrollment

Registered

2018-03-06

Start date

2018-04-04

Completion date

2018-05-25

Last updated

2019-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Serum/plasma (blood) is routinely used for measurement of albumin/creatinine in the critically ill. However, point-of-care (POC) urinary albumin/creatinine testing in patients admitted to the Intensive Care Unit (ICU) may be advantageous due to the rapid availability of results. To date, the accuracy of POC urinary albumin/creatinine compared to laboratory analysis in this population has not been evaluated. The anticipated outcome of this project is that if agreement is detected between POC and laboratory analysis, then POC testing may be a valuable methodology for measuring urinary albumin/creatinine in critically ill patients. This could have useful applicability for rapid assessment of results, therefore predicting prognosis and mortality in this population.

Interventions

Enrolled patients will have 5ml of urine taken from the in situ catheter and analyzed on the point-of-care analyzer and sent for labratory analysis at SA pathology. Urine samples will be taken by a trained clinical researcher, whom is also trained and efficient with the point-of-care analyser being used.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

• >18 years of age • Arterial line in situ • Catheter in situ

Exclusion criteria

Exclusion criteria are conditions which affect albumin/creatinine results including patients with anuria or haematuria; pre-existing chronic kidney disease (as defined by an abnormal creatinine on previous testing if available); pre-existing diabetes mellitus; known proteinuria due to renal or post-renal causes and urinary tract infection.

Outcome results