None listed
Conditions
Brief summary
The purpose of this study is to evaluate the effect of MitoQ supplementation on exercise training induced adaptations and exercise performance. Furthermore, the study aims to evaluate the effect of MitoQ supplementation on the cellular signalling response to a single bout of exercise and biomarkers which can be used to assess skeletal muscle and metabolic health following multiple (training) bouts of high intensity interval exercise. Finally, the study will enable the researchers to identify novel biomarkers which can be used to assess skeletal muscle and metabolic health, and the response to high intensity interval exercise. We hypothesise that multiple (training) sessions of high intensity interval exercise will improve exercise performance and this will be enhanced by MitoQ supplementation. Furthermore, enhanced exercise performance in the MitoQ supplemented group will be associated with elevated cellular signalling and biomarkers of skeletal muscle and metabolic health.
Interventions
The study contains two arms; treatment (Arm 1) and placebo (Arm 2). Participants in Arm 1 will be asked to consume one MitoQ oral capsule (containing mitoquinol mesylate equivalent to 20mg mitoquinol) per day for 5 weeks. Adherence to the supplement protocol will be monitored via tablet return.
Participants in both arms will undergo high intensity interval exercise training. Participants will be asked to come to the University of Auckland Grafton campus to complete 10 face-to-face training sess
The study contains two arms; treatment (Arm 1) and placebo (Arm 2). Participants in Arm 1 will be asked to consume one MitoQ oral capsule (containing mitoquinol mesylate equivalent to 20mg mitoquinol) per day for 5 weeks. Adherence to the supplement protocol will be monitored via tablet return. Participants in both arms will undergo high intensity interval exercise training. Participants will be asked to come to the University of Auckland Grafton campus to complete 10 face-to-face training sessions over a period of 3 weeks, which will be supervised by the researcher. During the first week participants will complete 3 sessions of 8 repeated 60s intervals of high-intensity stationary cycling (at 100% peak power output determined from VO2max test) with 75 s of recovery between each repetition .Training sessions in the first week are expected to last around 30 minutes, including a 5 minute warm-up and 5 minute cool down. During the second week participants will complete 3 sessions of 10 repeated 60s intervals of high-intensity stationary cycling (at 100% peak power output determined from VO2max test) with 75 s of recovery between each repetition. Training sessions in the second week are expected to last around 35 minutes, including a 5 minute warm-up and 5 minute cool down. During the third week participants will complete 4 sessions of 12 repeated 60 s intervals of high-intensity stationary cycling (at 100% peak power output determined from VO2max test) with 75 s of recovery between each repetition. Training sessions in the third week are expected to last around 40 minutes, including a 5 minute warm-up and 5 minute cool down. Training sessions will be separated by at least one day and no more than 4 days,
Sponsors
Faculty of Medical Health Sciences, The University of Auckland
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
Male
Age
35 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Male 35-60 years Sedentary to moderately active (no running or cycle training and no more than 3 hours of sport per week. No more than 2 resistance training sessions per week) Healthy BMI between 20 and 30
Exclusion criteria
Any chronic or advance health conditions or injuries History of alcohol abuse Smoking Taking medications which may affect exercise responses Antioxidant supplement intake in the previous 2 months
Outcome results
None listed