Electroanatomical Remodeling of the Atria in Obesity: Impact of the Adjacent Epicardial Fat

Electroanatomical Remodeling of the Atria in Obesity patients undergoing AF ablation: Impact of the Adjacent Epicardial Fat

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12618000166279

Acronym

N/A

Enrollment

Registered

2018-02-02

Start date

2011-12-01

Completion date

2012-12-01

Last updated

2018-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The study aims to delineate the electroanatomical remodelling in obese patients with atrial fibrillation. Importantly, it will analyse the impact of contiguous epicardial fat deposits on the electrophysiological properties of adjacent atrial tissue. It is a retrospective study based on the analysis of prospectively collected database. The patients underwent cardiac MRI prior to the ablation. Electrical remodelling and fat deposits and their association will be analysed

Interventions

This is an observational study where data is collected from investigations and electrophysiology study prior to ablation for atrial fibrillation. There is no follow up for the patients. The data collected will with 1) electrical atrial remodelling: a) voltage, b) fractionation, c) conduction velocity. The cardiac MRI will be analysed for 1) cardiac structure and function and 2) epicardial fat.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

The inclusion criterion was (1) Symptomatic AF refractory to at least one anti-arrhythmic medication.

Exclusion criteria

The exclusion criteria were (1) long standing persistent AF; (2) previous left atrial ablation; (3) contraindication for cardiac magnetic resonance imaging (CMR); (4) restrictive or hypertrophic cardiomyopathy; (5) valvular heart disease; (6) left ventricular dysfunction with LVEF<45%; (7) uncontrolled hypertension with left ventricular hypertrophy (LV wall thickness 12mm or more); (8) uncontrolled diabetes mellitus with HBA1C >7%; (9) amiodarone use in previous 6 months; (10) left atrial thrombus; (11) atrial arrhythmia > 30 seconds in the 7 days prior to the procedure by continuous ambulatory monitoring; (11) pregnancy and (12) inability to provide informed consent.

Outcome results