None listed
Conditions
Brief summary
The aim of this study is to see whether fructose elevates triglyceride acutely and whether this gets worse after a month of consumption of fructose muffins. Overweight or obese volunteers underwent 2 acute fat tests over 3 hours with 2 muffins sweetened with sucrose or fructose. This was repeated after a month of consumption of 2 low fat muffins/day sweetened with either sucrose or fructose. Endpoints were area under the curve for triglyceride and glucose and weight
Interventions
2 X80g high fat muffins (30% fat) containing 21g sucrose per muffin then 2 X80g high fat muffins (30% fat) containing 21g fructose per muffin (in random order one week apart) in 2 acute studies (3 hour study with blood samples taken at baseline, 30,60.90,120,150 and 180 minutes) immediately followed by 4 weeks of 2 X80g low fat muffins (15% fat)/daily containing 21g fructose per muffin followed immediately by a repeat of the two acute studies.
Compliance assessed by checklist and frozen m
2 X80g high fat muffins (30% fat) containing 21g sucrose per muffin then 2 X80g high fat muffins (30% fat) containing 21g fructose per muffin (in random order one week apart) in 2 acute studies (3 hour study with blood samples taken at baseline, 30,60.90,120,150 and 180 minutes) immediately followed by 4 weeks of 2 X80g low fat muffins (15% fat)/daily containing 21g fructose per muffin followed immediately by a repeat of the two acute studies. Compliance assessed by checklist and frozen muffin return.
Sponsors
university of SA
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Overweight or obese BMI>25
Exclusion criteria
type 2 diabetes
Outcome results
None listed