None listed
Conditions
Brief summary
There is some evidence that artificial sweeteners are associated with an increased risk of type 2 diabetes and in some studies this risk is greater in normal weight people. Clinical trials have not shown a definite increase in risk but a small study has shown that saccharin increases glucose intolerance in 4 days in half of the people studied. A second study showed that sucralose and AceK increased glucose absorption by 25-30%. We aim to investigate 2 weeks of usual artificial sweetener intake and measure 24 hour glucose levels over 2 weeks in response to normal foods and glucose, insulin and c peptide response to 75g of glucose before and after exposure to the sweetener and the control drink. We will examine normal weight and overweight men and women.
Interventions
500ml/day of artificially sweetened beverages containing aspartame (211mg/L) and acesulphame K (144mg/L) for 2 weeks.
Compliance will be assed by returned empty bottles
Washout will be 4 weeks
Sponsors
University of SA
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
No known diabetes or pre diabetes Normal weight volunteers BMI 18-25 Overweight/obese volunteers BMI>25
Exclusion criteria
To be included volunteers must have no use at all of artificial sweeteners in the last 6 months
Outcome results
None listed