None listed
Conditions
Brief summary
Postprandial (post-meal consumption) blood sugar level has been implicated in the development of obesity, type 2 diabetes and cardiovascular disease. It has been indicated that a rapid rate of rise followed by slower decline in the blood glucose levels post meal consumption are linked with fat deposition and adversely affect metabolic health. Curcumin, a bio-active ingredient obtained from the spice turmeric, is a potent anti-inflammatory agent, which is being now evaluated for its effects for controlling post meal blood sugar levels. Long chain omega 3 fatty acids (eicosapentanoic acid and docosahexaenoic acid) are established triglyceride lowering agents which are primarily obtained from fish or fish oil. The current purpose of this study is to evaluate the efficacy of a single dose of dietary supplements (curcumin and/or fish oil) on the post meal blood glucose rise in healthy individuals.
Interventions
Participants will visit Nutraceuticals clinical research rooms after an overnight fast of at least 10 hours. Following arrival, study participants will be randomly allocated to a single dose of these treatment arms on four visit days before receiving a standardised meal.
1. Placebo: 4 oral capsules (2 each for matching for curcumin and matching for fish oil placebos)
2. Curcumin (2 tablets @500 mg each) providing 180 mg curcumin plus 2 placebo matching for fish oil capsule
3: Fish oil (2 cap
Participants will visit Nutraceuticals clinical research rooms after an overnight fast of at least 10 hours. Following arrival, study participants will be randomly allocated to a single dose of these treatment arms on four visit days before receiving a standardised meal. 1. Placebo: 4 oral capsules (2 each for matching for curcumin and matching for fish oil placebos) 2. Curcumin (2 tablets @500 mg each) providing 180 mg curcumin plus 2 placebo matching for fish oil capsule 3: Fish oil (2 capsules @1000mg each) providing 1.2g EPA/DHA plus 2 placebo matching for curcumin capsules. 4: Curcumin (2 tablets @500 mg each providing a total of 180 mg curcumin) and fish oil (2 capsules @1000mg each providing a total of 1.2g EPA/DHA) Standardised meal included: 2 toasted white bread slices, 22g of peanut spread and chocolate flavoured milk. Participants receive treatments with a washout period of one week. Tablets/Capsules will be provided to the participants by the study investigator and are consumed before investigator. Participants are advised consuming the meal within 20 minutes.
Sponsors
University of Newcastle
Study design
Allocation
Randomised controlled trial
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
This study is suitable for you if: You are aged between 18-45 years You have body mass index (BMI) < 30 Kg/m2
Exclusion criteria
This study is not suitable for you if you have/are : Chronic or metabolic disease (eg: type 2 diabetes, cardiovascular disease) Auto-immune disease (rheumatoid arthritis, type 1 diabetes, lupus) Liver disease and Anaemia On medications for control of blood glucose levels Neurological diseases or seizures On regular dietary supplements are known to influence blood glucose level Pregnant, planning to become pregnant or breastfeeding Difficulties in providing blood sample Difficulties in providing informed consent Sensitivity/ intolerance to the products involved in this study
Outcome results
None listed