None listed
Conditions
Brief summary
Older patients who undergo surgery are more likely to have complications and prolonged recovery after their operation. One of the things which can predict recovery after surgery in older patients in frailty. Frailty results from age-related changes and affects people’s ability to tolerate medical treatments, including operations. This is an observational study which will be looking at older people who are having colorectal surgery. We will measure the frailty of the participants using a frailty assessment tool. We will also measure their daily activity levels with a watch that counts steps, and the function of their mitochondria, which is the part of the cell that produces energy. We will follow these people after their operation to see how well they recover. We aim to investigate the relationship between frailty, activity levels and the function of the mitochondria, and see if these things are associated with how well patients recover following an operation.
Interventions
This will be an observational study of older patients undergoing elective colorectal surgery.
Patients will be recruited at least two weeks and not more than six months prior to surgery.
Markers of frailty will be assessed preoperatively using three different measures.
1. An edmonton frailty scale score (EFS) will be recorded two weeks prior to scheduled surgery
2. Activity levels (using a step counter) will be measured for 10- 14 days prior to scheduled surgery.
3. A blood test assessing m
This will be an observational study of older patients undergoing elective colorectal surgery. Patients will be recruited at least two weeks and not more than six months prior to surgery. Markers of frailty will be assessed preoperatively using three different measures. 1. An edmonton frailty scale score (EFS) will be recorded two weeks prior to scheduled surgery 2. Activity levels (using a step counter) will be measured for 10- 14 days prior to scheduled surgery. 3. A blood test assessing mitochondrial function which has been associated with ageing will be performed at two weeks prior to scheduled surgery. Other than the assessment of these frailty markers, patients will undergo routine perioperative care. Post operatively, patients will be followed for 100 days and observed for a number of outcomes (specified further in section 4) EFS will be repeated on day 30 postoperatively Mitochondrial function blood test will be repeated on day 2 and day 30 postoperatively Activity levels will be measured from day 2 postoperatively for 14 - 28 days
Sponsors
University of Otago Christchurch
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Those included in this study will • Be undergoing an elective colorectal surgical procedure within the next 6 months • Be aged 65 years or over • Be ambulatory, including with the use of walking aids such as sticks or frames
Exclusion criteria
• Unable to obtain valid consent • Stoma reversal surgery • Non general-surgical abdominal procedures (ie vascular procedures) • Non-ambulatory/mobilises in wheelchair • Emergency surgery • Date of recruitment less than 2 weeks before admission date • Dermatitis or skin lesions of the upper limb that would prevent safe and comfortable wearing of the activity tracking device • Regular participation in moderate to high intensity physical activity not detected by activity tracking device, such as cycling or swimming
Outcome results
None listed