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The effect of resistance training on the human gut microbiota.

The effect of resistance exercise training on the composition and diversity of the human gut microbiota in healthy sedentary individuals.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12617001620314
Enrollment
22
Registered
2017-12-11
Start date
2018-01-08
Completion date
2019-04-16
Last updated
2019-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary purpose of the study is to examine the effect of resistance exercise training and its associated adaptations on the human GI microbe profile. It is hypothesised that 12 weeks of resistance exercise training will significantly alter the composition and diversity of the gut microbiota when compared to a non-exercise control group. This research may enable for the development of exercise guidelines focused on gut microbiota health and play an integral role in furthering exercise physiology practice.

Interventions

Exercise Intervention Participants randomised to the intervention group will complete a 12-week supervised resistance exercise training program prescribed three times per week on non-consecutive days. Each session will last approximately 60 minutes and consist of either one-on-one or group training with multiple participants (2–5) per trainer. The exercise prescription will be split into two 6-week programs progressing from machine-based prescription to free weight-style prescription. Following

Exercise Intervention Participants randomised to the intervention group will complete a 12-week supervised resistance exercise training program prescribed three times per week on non-consecutive days. Each session will last approximately 60 minutes and consist of either one-on-one or group training with multiple participants (2–5) per trainer. The exercise prescription will be split into two 6-week programs progressing from machine-based prescription to free weight-style prescription. Following 5-10 minutes of light intensity warm-up, participants will complete 7-8 exercises targeting all the major muscle groups of the body. Three sets of 8-10 repetitions will be performed of each exercise prior to moving on to the following exercise. Sets will be performed to the point of concentric muscular fatigue, with the load being adjusted for each exercise to ensure fatigue is achieved in the target repetition range. Exercises will be substituted when deemed necessary due to musculoskeletal limitations. Participants will keep an exercise diary (completed at the supervised sessions) to monitor adherence to and progression of their programs. Intervention group participants will be instructed to refrain from performing any additional resistance-type or aerobic training for the duration of the study. A qualified exercise physiologist (Mr Alan Ezzy) will supervise all routines. Mr Ezzy holds a Bachelor of Exercise and Sports Science (Clinical Exercise Physiology) - 1st Class Honours from the University of New England. Mr Ezzy also has 12 months recent experience (2016) practicing as a clinical exercise physiologist. The intervention will take placein the exercise physiology laboratory on-campus at the University of New England, Armidale, NSW Australia.

Sponsors

University of New England
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy, normal - high body mass index (BMI between (greater or equal to) 18.5 and (less than) 30.0 kg/m^2), currently sedentary (<150 min of structured exercise per week, no current resistance training).

Exclusion criteria

Inability to provide informed consent Any previous or current chronic health conditions Any musculoskeletal injury which may affect ability to perform resistance exercise Any previous or current gastro-intestinal or immune pathologies (including gastrointestinal surgery) History of chronic alcohol consumption Chronic habitual smoking within the last 6 months History of mental health conditions or illness within the last 6 months Oral antibiotics use within the last 6 months Chronic non-steroidal anti-inflammatory use within the last 6 months Have taken any probiotic supplement or supplements to improve gut health within the last 6 months Any regular structured aerobic or resistance-based exercise (>150 min per week) within the last 6 months. Pregnancy or lactation

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026